| Objective:To understand the epidemiological characteristics of acute drug poisoning in a tertiary hospital in Kunming,provide scientific basis for the formulation of targeted preventive measures and treatment plans.Method:From January 2015 to June 2020,patients with acute drug poisoning admitted to the Department of Emergency Medicine of the Second Affiliated Hospital of Kunming Medical University were the subjects of study.Using retrospective research method,self-designed data collection form was used to collect general information,poisoning status,treatment history and prognosis of selected patients.Use IBM SPSS25.0 statistical software for statistics to analyze the epidemiological characteristics of acute drug poisoning in a tertiary hospital in Kunming.Results:A total of 581 patients were included in this study.1.The general characteristics of the patients are:424 cases of women,157 cases of men,and the ratio of male to female is 1:2.7;the age group is mostly young,with 286 cases,accounting for 49.23%;the occupational distribution is staffed with 175 cases.Accounted for 30.12%;the education level is highest in high school,with 177 cases,accounting for 30.46%;among the poisoned patients,there are 241 cases with a history of disease,accounting for 41.48%,and mental illness is the most in patients with a history of disease,with 113 cases,accounting for 19.45%.2.The patient’s poisoning situation is as follows:the main route of poisoning is through the digestive tract,574 cases,accounting for 98.80%,the most common cause of poisoning is suicide,488 cases,accounting for 83.99%;the main source of drugs is self-purchasing,with 415 Cases,accounting for 71.43%,the most types of drugs are antipyretic analgesics,with 218 cases,accounting for 37.52%;the severity of poisoning is mainly mild,with 391 cases,accounting for 67.30%.3.The patient’s treatment situation is as follows:the time of visit was concentrated between 21:00-23:59,112 cases,accounting for 19.28%;treatment methods included removal of poisons,specific antidote and symptomatic supportive treatment;the most average number of observation days was within 2 days,there are 382 cases,accounting for 65.75%.4.The prognosis is mainly cured,with 551 cases,accounting for 94.84%.Conclusions:Patients with acute drug poisoning in a tertiary hospital in Kunming have obvious epidemiological characteristics in terms of general characteristics and poisoning conditions,and the overall prognosis is good.The results of this study are expected to provide a certain scientific basis for the formulation of acute drug poisoning preventive measures and first aid programs that are in line with the actual situation of the hospital.Objective:Analyze the independent risk factors of liver injury caused by acute drug poisoning in a tertiary hospital in Kunming,and provide scientific basis for formulating targeted preventive measures and emergency treatment plans.Method:From January 2015 to June 2020,eligible patients with acute drug poisoning admitted to the Department of Emergency Medicine of the Second Affiliated Hospital of Kunming Medical University were the research objects.The patients were divided into liver injury group and non-liver injury group.Using retrospective research methods,self-designed data collection forms were used to collect general information,poisoning status,treatment status,and biochemical indicators of selected patients.Use IBM SPSS 25.0 statistical software to compare whether the differences between the two groups are statistically significant,the statistically significant indicators are included in the multivariate logistic regression to analyze the independent risk factor of liver injury caused by acute drug poisoning in a tertiary hospital in Kunming.Results:A total of 566 patients were enrolled in this study,including 445 in the non-liver injury group and 121 in the liver injury group.1.General characteristics:The gender and age differences between the two groups are statistically significant.①In the non-liver injury group,there were 107 males,accounting for 24.00%,338 females,accounting for 76.00%,liver injury group,47 males,accounting for 38.80%,74 females,accounting for 61.20%(p=0.001);②Age(years):29(19,48.25)in the non-liver injury group,49.50(26.00,73.00)in the liver injury group(p<0.001).2.Poisoning situation:The difference between the time from taking poison to the doctor and the severity of poisoning between the two groups was statistically significant.①Time from taking poison to the doctor(hours):2.00(1.00,5.00)in the non-liver injury group,8.00(2.00,49.50)in the liver injury group(p<0.001);②The severity of poisoning in both groups was mainly mild There were 322 cases in the non-liver injury group,accounting for 72.40%,and 58 cases in the liver injury group,accounting for 47.90%(p<0.001).3.Treatment status:The difference in the number of cases of gastric lavage,catharsis and hemoperfusion between the two groups was statistically significant.①Number of gastric lavage cases:318 cases in the non-liver injury group,accounting for 71.50%,45 cases in the liver injury group,accounting for 37.20%(p<0.001);②Number of catharsis cases:339 cases in the non-liver injury group,accounting for 76.18%,There were 63 cases in the liver injury group,accounting for 52.10%(p<0.001);③Number of hemoperfusion cases:83 cases in the non-liver injury group,accounting for 18.65%,and 10 cases in the liver injury group,accounting for 8.26%(p=0.006).4.Biochemical indicators:The differences in D-D,Lac,WBC,NEUT between the two groups were statistically significant.①D-D(pg/L):1.20(0.60,1.60)in the non-liver injury group;1.30(0.83,2.80)in the liver injury group;②LAC(mmol/L):1.90(1.70,2.50)in the non-liver injury group;The liver injury group was 2.35(1.70,4.24);③WBC(109/L):the non-liver injury group was 8.78±3.27,the liver injury group was 11.76±5.23;NEUT(109/L):the non-liver injury group was 5.68(4.24,7.91);the liver injury group was 9.06(5.41,11.41).5.Independent risk factors:male,older,long time from taking poison to the doctor are independent risk factors,and hemoperfusion is a protective factor.①The partial regression coefficient of gender is 0.595,the odds ratio is 1.814,and the 95%confidence interval is[1.065,3.089],p=0.028;②The partial regression coefficient of age is 0.015,the odds ratio is 1.015,and the 95%confidence interval is[1.002,1.029],p=0.025;③The partial regression coefficient of the time from taking poison to the doctor is 0.046,and the odds ratio is 1.047,95%confidence interval Is[1.026,1.068],p<0.001;④The partial regression coefficient of hemoperfusion is-1.666,the odds ratio is 0.189,and the 95%confidence interval is[0.077,0.463],p<0.001.Conclusions:Male,old age,and long time from taking poison to medical treatment are independent risk factors for liver injury caused by acute drug poisoning in a tertiary hospital in Kunming,and hemoperfusion is protective factor.Formulating prevention and treatment measures for specific independent risk factors and actively performing hemoperfusion for necessary patients may be the key to reducing the incidence of liver injury caused by acute drug poisoning in our hospital... |
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