Study On The Correlation Between Common Syndrome Types And Micro-inflammation Of Diabetic Nephropathy And Summary Of Professor Wei Junping's Medication Experience

Objective1.Mining and sorting out the prescriptions and TCM syndrome data of Professor Wei Junping’s outpatient clinic on diabetic nephropathy,and summarizing the medication rules and experience.2.To analyze the clinical features of microinflammation and the correlation between TCM syndromes and microinflammation.Method1.Based on data mining,discuss the rules and experience of Professor Wei Junping’s treatment of diabetic nephropathy:data mining of 182 prescription data of Professor Wei Junping’s treatment of diabetic nephropathy.2.Research on the effects of TCM syndromes and inflammatory factors in patients with diabetic nephropathy:Statistics study methods were used to investigate the basic conditions of 60 newly diagnosed patients with type 2 diabetes or diabetic nephropathy,TCM symptoms,syndrome types of traditional Chinese Medicine,and inflammation indicators.analysis.Result:1.The first part discusses the medication rules and experience of Professor Wei Junping in treating diabetic nephropathy based on data mining1.1 Descriptive statistical resultsAn average of 16 Chinese herbal medicines are used per prescription,among which the 10 most frequently used Chinese herbal medicines are:Poria,Rehmanniaglutinosa,corn beard,peony bark,Alisma,Achyranthes,Pueraria lobata,Chuanshanlong,Scutellariabaicalensis,and raw astragalus.1.2 Association rule search resultsThe association rules of all commonly used drug combinations for prescriptions are searched to determine the commonly used drug combinations.The drug combination with support and confidence higher than 50%in the two-flavor medicine group is mostly related to"Poria";the confidence and support in the three-drug group The highest degree combinations are "Poria Alisma and Radix Rehmanniae".1.3 Cluster analysis resultsTaking all prescriptions of TCM syndromes as the basis for cluster analysis,it is divided into five categories:"hepatic and kidney disease position","spleen and kidney disease position","spleen liver and kidney disease position","kidney disease position" and "spleen and stomach disease position".Among them,the "spleen and kidney" prescriptions prefer calmness,the"liver and kidney" and "kidney" prescriptions tend to be cold,and the "liver,spleen and kidney"prescriptions tend to be warm.2.The second part of diabetic nephropathy patients with TCM syndromes and the influence of inflammatory factors2.1 Comparison of general information between the two groupsOf the 60 patients,20 were diabetic and 40 were diabetic nephropathy.There is no statistical difference between the general information of the two groups,and the two groups can be compared.2.2 Comparison between two sets of biochemical dataComparing the biochemical indicators between the two groups,compared with the diabetes group,the creatinine clearance rate of the diabetic nephropathy group was increased(P<0.05).Fasting blood glucose,blood lipids and other indicators were not statistically different between the two groups(P>0.05).2.3 Comparison of inflammatory factors between the two groupsThe level of IL-6 in the diabetic nephropathy group was significantly higher than that in the diabetic group(P<0.01),and there was no difference of IL-18,CRP and TNF-α.2.4 Comparison of TCM syndrome scores of two groups of patients Compared with the TCM syndrome scores of the two groups,compared with the diabetes group,the scores of kidney yin deficiency and blood stasis in the diabetic nephropathy group were significantly increased(P<0.05),and other syndrome scores were not statistically significant.2.5 Correlation analysis of inflammatory factors and TCM syndromes in all patientsThe correlation test between the levels of inflammatory factors and TCM syndrome scores showed that there was no statistically significant correlation between the TCM syndrome scores of the whole sample and CRP,TNF-α,IL-6 and IL-18.Conclusion:Professor Wei Junping treats the syndromes of diabetic nephropathy.The medication involves more than 170 flavors,mainly from the treatment of spleen,liver,and kidney.It focuses on the treatment of nourishing essence and blood,opening and closing Qi,and promoting blood circulation and dampness.Through data mining,empirical medications based on 28 drugs such as Poria,Corn Mustard,Rehmanniaglutinosa,Alisma orientalis,etc.are established,and different drug combinations are available according to the change of disease syndrome.The top 30 drugs used in the frequency are Poria,Rehmanniaglutinosa,Corn beard,Peony bark,Alisma,Achyranthes,Pueraria lobata,Chrysanthemum,Radix Scutellariae,Radix Astragali,Jiushoucornus,Raw Atractylodes,Chinese yam,Salvia miltiorrhiza,Radix Paeoniae Alba,white peony root,vinegar Chinney gold,plantain,radix rehmanniae,honey licorice,aronia,codonopsis,angelica,fried cassia,leeches,gastrodiaelata,wild chrysanthemum,chrysanthemum root,Ophiopogon japonicus,Ophiopogon japonicus,mulberry.From the perspective of efficacy,these medicines include tonics,heat-clearing medicines,diuretic medicines,blood circulation and blood stasis medicines,anti-drug medicines,rheumatism medicines,astringent medicines,digestive medicines,pingganxiefeng medicine and humidification medicine Medicine,in which tonicity,clearing heat,diuresis and dampness,and promoting blood circulation and removing blood stasis are the main effects of high-frequency medicine.From the perspective of recuperation and sexual taste,the drugs used in high frequency mainly belong to the liver,kidney,spleen and their superficial and internal meridians,and are mainly composed of Ping,Liang,Gan,and Ku.Studies on the correlation between microinflammatory inflammatory factors and TCM syndromes have found that compared with patients with diabetic non-nephropathy,patients with diabetic nephropathy have higher levels of microinflammatory inflammatory factors.At the same time,the score of kidney yin deficiency and blood stasis syndrome in diabetic nephropathy group was higher than that in diabetic nephropathy group.