Research On Drug Relationship Network For Treating Osteoarthritis Towards Compound Drug Design

Osteoarthritis,a debilitating degenerative joint disease predominantly found in elderly individuals,is the principal source of physical disability resulting in increased health care costs and impaired quality of the patients.With the accelerated aging of the population,the prevalence of osteoarthritis is also increasing year by year.Its main feature is the gradual degradation of the cartilage.Osteoarthritis is a kind of complex disease,its causes,complex factors,it is also a long-standing problem in the design of combination drug,the subject on the basis of osteoarthritis based on disease-related proteins,based on the proposed target bone arthritis Research combination drug design methods,resulting in a combination of the angle of the target put forward a new method for drug design.Based on available clinical data obtained with the human body associated with osteoarthritis disease-related protein,and then treating osteoarthritis drugs currently used for parsing mechanism,Thus obtained from the drug-drug target-processes in vivo-disease related protein-analysis result of the disease,then the results obtained by the network visualization,you can clearly see how each of the drugs play a therapeutic role.From the drug into the body to act on the corresponding drug targets,and then participate in the processes in vivo,which involves a protein,small molecules,and finally act on one or more of osteoarthritic disease-related proteins associated,thereby osteoarthritis impact.The treatment of osteoarthritis has long been a single medication for treatment,targets a single,so this topic proposed "Chemical Medicine Pair" concept,All results of the relationship between them which can cover more targets,the mechanism of the drug before getting a single chemical analytical network twenty-two merge through network visualization can be obtained when the two drugs,obtained by treatment effects classification.Osteoarthritis is a complex disease,different patients in the event of sickness related to the target are not the same,so the treatment can be administered in accordance with the combination of Chemical medicine on target to different patients.Finally,combined the 36 kinds of treating osteoarthritis currently listed chemicals,drug targets,drug in the treatment of osteoarthritis in vivo role of networks as well as all disease-related protein with osteoarthritis to obtain the medicine of OA and the diseases relationship network,and visualization the network,so it can be more intuitive to see each progress drug in the treatment of osteoarthritis is how it works,the relationship between their targets and pathways through which the body.In this paper,we use the entity grammar system as a guide,the current listing of osteoarthritis drugs,drug targets,disease-related proteins as a research object,and on the basis of traditional Chinese medicine on the proposed "Chemical Medicine Pair" concept of exploring the listing interaction between the drugs.Construction drug targets-disease network models under the guidance of Entity grammar systems,thereby making drugs more clearly been demonstrated,we proposed a new method for drug treatment of osteoarthritis design,and we also provides a new method for the analysis of clinical medicine and drug efficacy.