| BackgroundParkinson’s disease（PD）is a degenerative disease of the nervous system,which will lead to varying degrees of cognitive impairment and thus bring about much of hazard to public health.In recent years,some researchers have found that hematological indexes such as hemoglobin,plasma homocysteine and uric acid are involved in the pathogenesis of cognitive impairment in Parkinson’s disease.At present,there are few relevant studies,and the relationship between cognitive impairment and these hematological indexes in patients with Parkinson’s disease is not clear.ObjectiveThe purpose of this study is to analyze the correlation between cognitive impairment and plasma hemoglobin,plasma homocysteine and uric acid levels in patients with Parkinson’s disease.The results are helpful to the early identification of patients with high risk of cognitive impairment and early prevention of cognitive impairment in patients with Parkinson’s disease.MethodA total of 78 patients with Parkinson’s disease which treated in the First Affiliated Hospital of Xinxiang Medical University from January 2019 to January 2022 were selected for the study.The PD patients were divided into two groups by Mo CA scores,cognitive impairment group（<26 points）and normal cognitive function group（≥26 points）.At the same time,50 healthy subjects who received physical examination in the First Affiliated Hospital of Xinxiang Medical University during the same period were selected as the control group.The general information and hematological indexes of the three groups were collected.Binary logistic regression was used to analyze the relationship between hematological indexes such as hemoglobin,homocysteine,uric acid and cognitive function in patients with Parkinson’s disease.Results1.The course of the disease in the cognitive impairment group of PD patients was higher than that in the normal cognitive function group,and the difference was statistically significant（P<0.05）.On gender and education level,there was no significant difference among the three groups（P>0.05）.There was no statistical difference in the age of the subjects in each group（P>0.05）.In terms of H＆Y staging,there was significant difference between the two groups of PD patients（P<0.05）.The staging of cognitive impairment group was higher,and cognitive impairment could occur in the early stage of PD.2.The level of homocysteine in the cognitive impairment group of PD patients was higher than that of the cognitive normal group and the control group,and the difference was statistically significant（P<0.05）.The levels of erythrocyte,plasma uric acid and creatinine were significantly lower than those in the control group（P<0.05）.The level of hemoglobin in the cognitive impairment group and cognitive normal group of PD patients were lower than that in the control group,and the difference was statistically significant（P<0.05）.3.There were significant correlations between the levels of hemoglobin,homocysteine,the course of PD and the cognitive level of PD patients（P<0.05）,but there was no correlation between serum uric acid and the cognitive level of PD patients,there was no correlation between serum uric acid and cognitive level in PD patients（P>0.05）.4.Binary logistic regression analysis showed that the level of homocysteine and the course of PD were independent risk factors for cognitive impairment in PD patients（P<0.05）.5.The ROC curve of homocysteine level and the course of PD predicting cognitive impairment in PD patients showed that homocysteine（AUC 0.940,95% CI: 0.888-0.991,P<0.001）and course of PD（AUC）0.716,95% CI: 0.599-0.832,P=0.001)were reliable predictors of cognitive impairment in PD patients.6.There were statistically significant differences in the Mo CA total scores,visuospatial and executive ability,naming,attention,abstract thinking,delayed recall,and orientation scores among the three groups of subjects（P<0.05）.There was no statistical difference in language scores（P>0.05）.7.The level of homocysteine was negatively correlated with Mo CA total score,visuospatial and executive ability,naming,attention,abstract thinking,delayed recall,and orientation（P<0.05）,but no significant correlation with language（P> 0.05）.Conclusion1.Homocysteine and hemoglobin levels have a certain correlation with cognitive impairment in PD patients,not related to serum uric acid level;and homocysteine level is a reliable predictor of cognitive impairment in PD patients.2.The course of PD is related to cognitive impairment in PD patients,and those with a longer course of PD are more likely to have cognitive impairment. |
PDF Full Text Request