Analysis Of Risk Factors For Intracranial Hemorrhage In Premature Infants In A Class A Tertiary Hospital In Enshi

Objective: This article provides a reference for preventing intracranial hemorrhage and improving the prognosis of premature infants with intracranial hemorrhage by analyzing the risk factors associated with the disease in a grade A hospital in Enshi area.Methods: The clinical data of premature infants hospitalized in the Department of Neonatology,Minda University Hospital affiliated to Hubei Minzu University from January 2018 to December 2019 and completed within 1week after birth with bedside cranial ultrasound were collected,and they were divided into the bleeding group and the non-bleeding group according to the ultrasound results.Statistical software SPSS22.0 was used for data analysis,univariate analysis was performed on the general information of premature infants,maternal status,birth status of premature infants,concomitant diseases,hospitalization plan and other indicators,and the independent risk factors of premature infants with intracranial hemorrhage were screened by multivariate Logistic regression analysis.Results: A total of 335 premature infants were included in this study,including 180 cases with intracranial hemorrhage,with an incidence of53.7%.Univariate analysis showed that gestational age,birth weight,maternal hypertension,chorioamnionitis,fetal distress,prenatal hormone therapy,abnormal umbilical cord,amniotic fluid fecal staining,1 min Apgar score ≤7,5 min Apgar score ≤7,acidosis,hypoxemia,hypercapnia,NRDS,anemia,coagulant function abnormality,thrombocytopenia,sepsis,electrolyte disorder,positive pressure ventilation at birth,the application of birth vascular active drugs,invasive mechanical ventilation,and peripherally inserted central catheter between the two groups have statistical significance（P < 0.05）.Logistic regression analysis of multiple factors showed that gestational age（OR=0.725,P=0.000）,prenatal hormone therapy（OR=0.338,P=0.000）,positive pressure ventilation at birth（OR=2.855,P=0.044）,NRDS（OR=5.985,P=0.000）and acidosis（OR=3.454,P=0.002）between the bleeding and non-bleeding groups have statistical significance.Conclusion: In this study,low gestational age,positive pressure ventilation at birth,NRDS and acidosis are independent risk factors for intracranial hemorrhage in premature infants.Prenatal corticosteroid therapy is independent protective factors for intracranial hemorrhage in premature infants.In clinical practice,reducing the occurrence of premature delivery,prenatal corticosteroid therapy,prevention and treatment of NRDS,strengthening resuscitation management in delivery room,monitoring and correcting acidosis are beneficial to reduce the occurrence of intracranial hemorrhage in premature infants.