| Objective:To explore the factors affecting the short-term efficacy of catheter-directed thrombolysis（CDT）in the treatment of lower extremity deep venous thrombosis（DVT）.Methods:A retrospective case-control study,the clinical data of 129 patients with lower extremity DVT who received CDT treatment from November 2017 to March 2021 in the First Affiliated Hospital of Bengbu Medical College were selected,including gender,age,course of disease,hypertension,diabetes,and malignant tumors,Fracture or trauma in the past month,pre-dilation of iliac vein balloon before CDT,leukocytes,platelets,fibrinogen,D-dimer,C-reactive protein,a total of 13 factors may affect the short-term efficacy of CDT.Among them,56 males and 73 females,aged（43.3±6.1）years old,were divided into two groups: recanalization（thrombectomy rate ≥ 50%）and non-canalization（thrombectomy rate < 50%）according to the CDT treatment effect.There were 57 cases in the recanalization group and 72 cases in the recanalization group.The clinical data of the two groups were analyzed by univariate,and the indicators with statistically significant differences（P<0.05）were analyzed by multivariate logistic regression.Results:there were 57 patients in non-patency group and 72 patients in recanalization group.Univariate analysis showed that there were significant differences in age,course of disease,malignant tumor,platelet,fibrinogen and iliac vein balloon pre-dilatation before CDT between the two groups.The results of multivariate logistic regression analysis showed that age（OR=2.734,95% CI: 1.115-6.704,P<0.05）,course of disease（OR=18.761,95% CI: 3.861-91.157,P<0.05）,fibrinogen（OR=1.518,95% CI: 1.085-2.125,P<0.05）and iliac vein balloon pre-dilatation（OR=0.167,95% CI: 0.038-0.744,P<0.05）.Conclusion: Age,course of disease,fibrinogen and iliac vein balloon dilatation before CDT are independent factors affecting the short-term efficacy of catheter thrombolysis. |
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