Evaluation Of The Correlation Between Immunological And Inflammatory Blood Indexes And Alopecia Areata

Background: The most common clinical manifestations of Alopecia areata（AA）are one or more well-demarcated round,quasi-round,oval or irregular Alopecia areata areas on the scalp,on the body or on the limbs with hair.The local skin appears normal and smooth under gross and dermatoscopy,without scales and inflammatory reactions.Although mostly spot bald patient has the possibility that heal oneself,but also have partial patient condition aggravation and appear more trichomadesis area,can gather bigger trichomadesis area,those who involve whole scalp call for complete bald,complete bald can involve eyebrow,beard,armpit hair,pubic hair even.Alopecia universalis is a rare disease with severe vellus hair loss.Of spot bald still include acute diffuse model（the hair of whole scalp suddenly all prolapse）,prostrate sex spot bald（pillow ministry and ear before and after the hairline place symmetry strip hair suddenly prolapse）wait for special type.For the patients themselves,alopecia areata not only affects the appearance of patients,but also affects their psychological development.Alopecia areata is an autoimmune disease and a chronic recurrent inflammatory disease.Therefore,patients with alopecia areata may be complicated with immune and inflammatory diseases,so it is very important to study the relationship between alopecia areata and immunological and inflammatory indicators.Objectives: The purpose of this project is to investigate several blood indexes of immunology and inflammation in patients with alopecia areata,evaluate the relationship between these indexes and the disease,so as to further explain the mechanism of alopecia areata in inflammation and immunology,and guide the clinical diagnosis and treatment of the disease.Methods: This study is a case control study,using retrospective analysis method.In this study,672 eligible alopecia areata patients who visited a grade A hospital in Hefei city from January 2016 to May 2020 were included,as well as 580 age-and sex-matched healthy control group.All patients met the clinical diagnostic criteria for alopecia areata,western medicine diagnostic criteria refer to Chinese Alopecia areata Diagnosis and Treatment Guidelines（2019）: 1.Clinical manifestation: Patches of hair loss that occur suddenly may be round,quasi-round or irregular in shape;2.Predilection sites: Scalp,also can involve eyebrow,beard,armpit hair,eyelash,pubic hair and so on;3.Clinical disease feature: Patients generally have no obvious conscious symptoms;4.Auxiliary examination: Hair pull test,histopathological examination and hair mirror examination.And the heart,liver,and kidney function of the subjects were normal,excluding those who were pregnant or lactating,had other immune diseases,or had incomplete clinical data.Serum c-reactive protein（CRP）,25-hydroxyvitamin D（25（OH）D）,triiodothyronine（T3）,tetraiodothyronine（T4）,thyroid stimulating hormone（TSH）,autoimmune thyroid antibodies（TPOAbs and TGAbs）,antinuclear antibodies（ANA）,complement（C3,C4）and several kinds of immunity Blood indexes such as globulin（Ig A,Ig M and Ig G）were analyzed statistically.The standard mean error（SEM）was used to represent all the collected index values.Independent T test was used for measurement data,chi-square test was used for positive rate comparison,and multivariate Logistic regression analysis was performed.Results:Statistical analysis showed that the average serum 25（OH）D concentration in alopecia areata group was significantly lower than that in control group（P < 0.05）,while the serum CRP concentration was significantly higher than that in healthy control group（P < 0.05）.In terms of immunity-related indexes,there was no significant difference in TSH,TGAbs,C3,C4,Ig A,Ig M and Ig G between the alopecia areata group and the healthy control group（P ≥ 0.05）.Only T3,T4,TPOAbs and ANA values of alopecia areata group were significantly different from those of healthy group（P < 0.05）.Conclusion: 1.AA was associated with a decrease in serum 25（OH）D and an increase in CRP,an inflammatory indicator;2.Serum TSH,TGAbs,complements and immunoglobulins were not associated with AA;3.Patients with AA have an increased risk of thyroid disease and autoimmune disease,so it is of certain clinical significance to detect serum thyroid hormone,thyroid peroxidase antibodies and ANA.