Short-term Efficacy Of ¹²⁵I Seed Brachytherapy Combined With Tace For The Liver Metastases And Its Impact On Hepatic Function And Peripheral Blood Cells

Objective To explore the short-term efficacy of hepatic arterial chemoembolization（TACE）combined with ¹²⁵I particles brachytherapy for the liver metastases and its impact on hepatic function and peripheral blood cells.Materials and methods A total of 54 patients with liver metastases were enrolled.Amongst,31 cases were treated with TACE only（control group）and 24cases were treated with TACE combined with ¹²⁵I particles brachytherapy（research group）.Indicators such as the short-term efficacy,hepatic function and peripheral blood cells were compared in the two groups.Results The effective rate（CR+PR）of the research group（42.9%）was higher than that of the control group（21.2%）,but the difference was not statistically significant（χ2=3.009,P=0.083）.The benefit rate（CR+PR+SD）of the research group（100%）was significantly higher than that of the control group（78.8%）,which was statistically significant（χ2=4.210,P=0.040）.The comparison of myelosuppression between them was not statistically significant（Z=1.609,P=0.108）.As for the comparison of them before treatment and within groups,hepatic function and the complications were not statistically significant（P>0.05）.Conclusion TACE combined with ¹²⁵I particles brachytherapy can effectively control the progression of liver metastases without any obvious complications.It is a safe and effective treatment.