Efficacy Of Sonazoid Contrast-enhanced Ultrasound In The Diagnosis Of Benign And Malignant Breast Masses

Background:In recent years,the incidence of breast diseases has continued to increase,and breast cancer has become the most common malignant tumor in women.Although the incidence of breast cancer is high,its mortality rate is not high,and the 5-year survival rate of patients has continued to improve in recent years.Early diagnosis is of great significance to the choice of treatment and prognosis of the patients of breast cancer.In recent years,the application of imaging techniques for early diagnosis of breast mass has always been a focus of clinical research.At present,the commonly used imaging techniques for breast cancer include mammography,ultrasound,and MRI.Mammography and conventional ultrasound are the routine methods for early breast cancer screening.However,there are many types of breast diseases,and there are many overlapping imaging images,which have certain limitations in the differential diagnosis of benign and malignant lesions.Enhanced imaging is recommended in clinical practice to differentiate benign and malignant breast lesions,and evaluate the degree of infiltration of lesions into surrounding tissues.Compared with enhanced MRI,CEUS,as a pure blood pool imaging technology,has real-time dynamic,good repeatability,safety and no radiation,it can clearly display tumor new microvessels,which is helpful to improve the diagnosis of breast cancer,the evaluation of postoperative efficacy and prognosis.Sonazoid,as a new generation of ultrasound contrast agents（UCAs）,has also achieved improvements in the diagnosis of liver diseases.At present,there are few studies on the use of Sonazoid-CEUS for the differential diagnosis of benign and malignant breast lesions,and there is a lack of relevant quantitative analysis studies.Objectives:This study was performed to evaluate and compare the effectiveness of qualitative and quantitative and combined analysis with Sonazoid-contrast-enhanced ultrasound（SonazoidCEUS）for the diagnosis of benign and malignant breast mass.Methods:A total of 40 patients（41 lesions）from October 2020 to June 2021 were enrolled in this study.All lesions underwent qualitative and quantitative enhancement evaluation with Sonazoid-CEUS.A single factor analysis of the results was performed.Among them,the statistically significant parameters was used for generating the logistic regression equation.Receiver operating characteristics（ROC）curve was drawn to analyze the diagnostic effectiveness for breast malignant mass.Result:Among the 41 breast lesions confirmed by puncture or surgical pathology,21 were benign,and20 were malignant.The univariate analysis results showed that the enhancement degree,enhancement speed,range of the lesion after enhancement,peripheral perforating or radial vessels,and enhancement margin in the qualitative patterns were significantly different（P<0.05）.The PI and △PI in the quantitative parameters were also significantly different（P<0.05）.The logistic regression equations for the qualitative,quantitative and combined analyses showed that the AUC values were 0.938,0.850,and 0.940,respectively;the sensitivity was 90%,75%,and90%,respectively;and the specificity was 95.2%,85.7%,and 95.2%,respectively.The diagnostic effectiveness of the qualitative analysis was superior to that of the quantitative analysis,showing a significant difference（P<0.05）.However,there was no significant difference between the qualitative analysis and combined analysis results（P>0.05）.Conclusion:Sonazoid-CEUS is a safe and effective method for the differential diagnosis of benign and malignant breast lesions.The diagnostic efficacy of qualitative analysis is superior to that of quantitative analysis,but there is no difference in the diagnostic efficacy compared with the combined analysis.