Correlation Of Serum PTX3 And Adiponectin Levels With Infarct Volume And Degree Of Neurological Deficits In Patients With Acute Cerebral Infarction

ObjectiveTo investigate the correlation between serum PTX3 and adiponectin levels and infarct volume and degree of neurological deficits in patients with acute cerebral infarction（ACI）,and to provide new research directions for the prevention and treatment of ACI..MethodsFrom October 2020 to December 2021,154 patients with acute cerebral infarction admitted to the Department of Neurology of the Central Hospital of Shenyang Medical College were selected as the observation group,and the neurological function of patients with cerebral infarction was evaluated according to the National Institute of Health stroke scale（NIHSS）score.The severity of neurological deficits was evaluated based on the NIHSS score,and the observation groups were divided into mild（NIHSS score<5）,moderate（5≤NIHSS score≤15）and severe（NIHSS score>15）groups.The Pullicino formula was used to calculate the infarct volume,and the infarct volume was divided into small volume group（infarct volume<5cm~3）,medium volume group（5cm~3≤infarct volume≤10cm~3）,and large volume group（infarct volume>10cm~3）according to the size of the infarct.Randomly selected 158 cases of healthy people who were examined in our hospital during the same period as the control group.The gender,age,history of hypertension,diabetes mellitus,smoking and alcohol consumption,TG,TC,HDL,LDL and Hcy were collected and recorded for the observation and control groups,and the serum PTX3 and adiponectin levels were examined.The differences in serum PTX3,adiponectin and Hcy levels between the observation and control groups were compared by t-test analysis,and the relationship between PTX3,adiponectin and Hcy indexes and acute cerebral infarction was compared by binary logistic regression analysis,and further one-way ANOVA analysis was used to compare PTX3,adiponectin and Hcy levels in small,medium and large infarct volumes in the observation group and in the mild,medium and severe groups.Adiponectin and Hcy levels in the small,medium and large infarct volumes and in the mild,medium and severe groups;the correlation between serum PTX3 and adiponectin levels and infarct volume and NIHSS score was analyzed by Spearman correlation analysis.ROC working curve plots were drawn to assess the risk of serum PTX3 versus adiponectin levels for the development of ACI.Results1.Compared with the control group,serum PTX3 and homocysteine levels were significantly higher and adiponectin levels were significantly lower in the observation group than in the control group,with statistically significant differences（P<0.01）.2.Binary logistic regression analysis with the presence or absence of ACI as the dependent variable and serum PTX3 and adiponectin levels as the independent variables showed that PTX3 and adiponectin levels were closely associated with the occurrence of ACI（OR=1.562,0.76,P<0.01）,PTX3 was a risk factor for the development of ACI,and adiponectin was a protective factor for the development of ACI,and proofreading of age PTX3 was still a risk factor for the development of ACI and adiponectin was a protective factor for the development of ACI after collating confounding factors such as age,gender,hypertension,diabetes,smoking and alcohol consumption（OR=0.758,P<0.01）.3.There were no statistically significant differences in age,gender,hypertension,diabetes,TG,TC,HDL and LDL levels between groups with different infarct volumes（P>0.05）,and there were significant differences in PTX3,adiponectin and Hcy levels with statistically significant differences（P<0.05）,and serum PTX3 and Hcy levels in the large infarct volume group were higher than those in the medium and small infarct volume groups The levels of serum PTX3 and Hcy in the large infarct volume group were higher than those in the medium and small infarct volume groups,and the levels of adiponectin in the medium infarct volume group were lower than those in the small infarct volume group,that is,the larger the volume of infarct foci,the higher the levels of serum PTX3 and Hcy,and the lower the levels of adiponectin.4.The differences in baseline data and lipid levels between groups with different degrees of neurological deficits were not statistically significant（P>0.05）,but there were significant differences in PTX3,adiponectin and Hcy levels,and the differences were statistically significant（P<0.05）,with PTX3 and Hcy levels in the severe group being significantly higher than those in the medium and mild groups,and in the medium group being higher than those in the mild group,while adiponectin levels in the severe group were significantly lower than those in the medium and mild groups The level in the moderate group was lower than that in the mild group,i.e.,the more severe the degree of neurological deficit,the higher the PTX3 and Hcy levels and the lower the adiponectin level.5.Spearman correlation analysis showed that PTX3 level was positivelycorrelated with infarct volume and neurological deficit in ACI patients,and adiponectin level was negatively correlated with it（P<0.01）.6.ROC curve analysis showed that the AUC values of serum PTX3 and adiponectin for detecting the risk of ACI were 0.754 and 0.707,respectively,and the AUC value of the combined test was 0.795,and their sensitivity and accuracy were higher than those of the single test,and the difference was statistically significant（P<0.05）.Conclusion1.Serum PTX3 and adiponectin levels were significantly correlated with the occurrence of ACI,and both increased serum PTX3 levels and decreased adiponectin levels were risk factors for the occurrence of ACI.2.The serum PTX3 and adiponectin levels were closely related to the size of infarct foci and the degree of neurological deficits in ACI patients,and the PTX3level was positively correlated with both,that is,the larger the infarct foci and the more severe the degree of neurological deficits,the higher the PTX3 level;the adiponectin was negatively correlated with both,that is,the larger the infarct foci and the more severe the degree of neurological deficits,the lower the adiponectin level.It can be one of the indicators to monitor the changes in the condition of ACI.3.Serum PTX3 and adiponectin levels may be predictors of the risk of ACI and have good predictive value for assessing the risk of ACI.