META Analysis Of Influencing Factors Of Periprosthetic Infection After Artificial Joint Replacement

Objective To investigate the risk factors of periprosthetic infection（PJI）after joint replacement in Chinese patients.To provide basis for the formulation of infection control strategy around prosthesis.Methods Chinese databases including CNKI,Wanfang,Chinese Biotechnology Journal,VIP Chinese Journal,and English databases including Embase,Web of Science,Cochrane Libarary,and Pub Med were searched from November 2013 to November2021.A meta-analysis was performed using Review Maneger 5.3 software and Stata16.0 software after evaluating the quality of the included literature.Results Twenty studies were included,including 8154 patients undergoing artificial joint replacement and 584 patients with PJI.Meta-analysis results showed that the incidence of PJI in Chinese patients after artificial joint replacement showed statistically significant differences among the following groups: Diabetes mellitus [OR=1.95,95%CI（1.63,2.34）],hormone administration history [OR=2.63,95%CI（1.90,3.65）],preoperative mean BMI[SMD=0.72,95%CI（0.56,0.89）],preoperative mean albumin level [SMD=-1.9,95%CI（-3.3,-0.5）],smoking history [OR=2.77,95%CI（1.28,5.99）],mean operation time [SMD=0.65,95%CI（0.44,0.86）],operation time≥180min[OR=1.36,95%CI（2.14,3.19）],operative time ≥120min[OR=1.68,95%CI（1.24,2.28）],postoperative drainage time ≥48h[OR=2.10,95%CI（1.35,3.27）],combined with other site infection [OR=3.71,95%CI（2.66,5.19）].Conclusion History of hormone administration,diabetes mellitus,smoking,BMI,preoperative albumin level,operation time,postoperative drainage time and other site infection are risk factors for PJI after artificial joint replacement.It is suggested that PJI is associated with multiple factors after artificial joint replacement,and clinicians should take effective measures to prevent the occurrence of this catastrophic complication.