Effect Observation Of Shengyang Sanhuo Decoction On Fever After TACE For Primary Liver Cancer

Objectives : To observe the clinical effect of Shengyang San-Huo Decoction on primary liver cancer patients with the postoperative after transcatheter hepatic arterial chemoembolization(TACE),and explore its mechanism.Methods: This study was a randomized controlled trial,including 28 cases in the observation group and 30 cases in the control group.All of them were given 3 days of postoperative replenish fluids,liver protection,stomach protection,infection prevention treatment,and according to the patient’s symptoms,were given antipyretic,analgesic,antiemetic.The observation group was given Shengyang San Huo decoction orally from the 1st day to the 7th day after the operation on the basis of treatment in the control group,and both groups were observed for 7 days.Comparison was made between the two groups in the number of postoperative fever,fever peak,range of hypothermia,the number of fever again after normal hypothermia,interval time,postoperative abdominal pain,functional status score and other differences.Results:(1)After comparative analysis,the baseline data of the two groups are consistent and comparable.In addition,the two groups of patients treated with antipyretic and analgesic therapy had no significant effect on the change of temperature,and the interference of such drugs could be eliminated.(2)In terms of the mean temperature,there was a significant difference in the decrease of body temperature between the two groups from 5 days after operation(P < 0.05),and the decreasing range and speed of the observation group was higher than that of the control group.(3)In terms of peak body temperature,the observation group is lower compared with the control group,but there was no significant difference between the two groups(P>0.05).(4)In terms of the postoperative fever rate,there was a statistically significant difference between the two groups at 6d and 7d after surgery(P<0.05),and the fever rate of the observation group was significantly lower than that of the control group.(5)In terms of the postoperative reheat rate and reheat duration,the observation group was better than that of the control group.(6)In terms of postoperative abdominal pain(pain in the liver area),there was no significant difference in NRS scores between the two groups(P>0.05).(7)In terms of of KPS scores before and after treatment,the postoperative quality of life of the two groups was stable.From the perspective of safety indicators,there was no significant difference between the two groups,and no serious adverse events in the course of the study.Conclusion: Shengyang Sanhuo decoction has a good effect on fever after TACE.It can reduce the rate of postoperative fever,and the temperature of patients with fever after operation,shorten the time of fever.However,there is no significant improvement in postoperative abdominal pain,which needs to be combined with other symptomatic treatment.