Evaluation Of The Clinical Efficacy Of Combining The Method Of Yiqihuoxue And Kuanxiongqutan In The Treatment Of Patients With Idiopathic Pulmonary Fibrosis

OBJECTIVE:To comprehensively evaluate the clinical efficacy of the treatment of IPF using the combination of " Yiqihuoxue and Kuanxiongqutan " in a randomized controlled clinical study.METHODS:In this trial,subjects who met the criteria were randomly divided into a test group and a control group.In the experimental group," Yiqihuoxue and Kuanxiongqutan " was used in combination with conventional Western medicine treatment,while in the control group,only conventional Western medicine treatment was used.The clinical efficacy of the treatment of IPF with the combination of " Yiqihuoxue and Kuanxiongqutan " was evaluated.RESULTS:1.Total effective rate: Test group: 57.1%,Control group:25.0%,P<0.05.2.Quantification of TCM symptoms: Before treatment,the total points and the points of each main symptom of cough,sputum and wheezing were compared between the two groups,P>0.05.After treatment,the total points and the points of each main symptom of cough,sputum and wheezing were compared before and after the two groups,P<0.05;compared between the two groups,P<0.05.3.Lung function:(1)Lung ventilation function: comparison of TLC% and FVC% between the two groups before treatment,P>0.05.After treatment,comparison of TLC% and FVC% between the two groups;comparison of TLC% and FVC% before and after in the test group,P>0.05;comparison of TLC% and FVC% before and after in the control group,P < 0.05.(2)Lung diffusion function: comparison of DLCO% between the two groups before treatment,P > 0.05.After treatment,comparison of DLCO%between the two groups,before and after within the two groups,P<0.05.4.Blood gas analysis: Before treatment,p H,Pa O2 and Pa CO2 were compared between the two groups,P>0.05.After treatment,p H and Pa CO2 were compared between the two groups,and p H and Pa CO2 were compared before and after the group,P>0.05;Pa O2 was compared between the two groups,and Pa O2 was compared before and after the group,P<0.05.5.6MWT:(1)Distance: comparison of distance between groups before treatment,P>0.05;comparison between two groups after treatment and before and after within two groups,P<0.05.(2)Borg dyspnoea score: comparison between the two groups before treatment,P>0.05.comparison between the two groups after treatment,P>0.05.After treatment,within-group comparison between the two groups,between-group comparison of the difference in Borg scores before and after treatment between the two groups,P<0.05.CONCLUSION:The Chinese and Western medical treatment of " Yiqihuoxue and Kuanxiongqutan " method was better than the conventional Western medical treatment in improving the patients’ Chinese medical symptoms,arterial blood oxygen partial pressure,pulmonary diffusion function,six-minute walk test distance and Borg dyspnea score;the combination of Chinese and Western medicine and Western medicine alone failed to reverse the decline in lung ventilation,but the combination of Chinese and Western medicine slowed the decline in lung ventilation dysfunction.