| Objectives : To explore the correlation between cerebal microbleeds andα-conuclein as well as other clinical indicators,and to provide guidance for the treatment and management of cerebral microbleeds.Method : Collecting clinical datas of patients with cerebral small vessel disease who were hospitalized in Provincial people’ Hospital of Hunan from January 2020 to February 2021,including age,gender,number and location of cerebral microbleeds,history of smoking and drinking,history of hypertension and diabetes,use of anti-polymeric drugs,homocysteine,blood lipids,CRP,fibrinogen and α-synuclein serum concentration,etc.All patients(N=148)were divided into two groups,cerebral microbleeds group(n=78)and control group(no cerebral microhemorrhage lesions,n=70),according to the presence or absence of cerebral microhemorrhage lesions.The clinical datas between the two groups were statistically analyzed.Data processing was carried out by SPSS24.0 statistical software.Continuous variables were represented by mean ± standard deviation,and variables of different types were expressed by frequency.Two independent samples t-test was used for comparing between two groups of continuous variables,and chi-square test was used for comparing between two groups of sub-type variables.Data differences among different groups were analyzed by One-way ANOVA,and logistic regression analysis was used for correlation analysis as needed.P<0.05 was considered statistically significant.Results:1.A total of 148 patients with cerebral small vessel disease were enrolled in this study,including 78 cases(52.7%)in the cerebral microbleeds group and 70 cases(47.3%)in the control group.A total of 427 microhemorrhage lesions were detected,including 212 lesions in cerebral lobes(25 in parietal lobe,74 in occipital lobe,65 in temporal lobes,48 in frontal lobe),66 in subtentorial lobes(28 in brainstem,38 in cerebellum),and 149 in deep lobes(149 in basal ganglia and thalamus).Among them,there were 42 patients with mild lesions(< 5 lesions),20 patients with moderate lesions(5-9 lesions),and16 patients with severe lesions(≥10 lesions).2.The serum levels of α-synuclein,homocysteine,high-density lipoprotein,and CRP in the cerebral microbleeds group were significantly higher than those in the control group(P<0.05).The proportion of patients with diabetes,hypertension or smoking history in cerebral microhemorrhage group was significantly higher than that in control group(P<0.05).There were no statistically significant differences in other observation indicators including age,gender,drinking history,anti-aggregation drug use history,fibrinogen,low-density cholesterol,and total cholesterol(P>0.05).3.Logistic regression analysis showed that cerebral microbleeds were associated with α-synuclein(OR=9.957,95% CI 2.373-41.772,P=0.002),homocysteine(OR=1.143,95%CI 1.055-1.238,P=0.001),CRP(OR=1.217,95% CI 1.079-1.372,P=0.001)and a history of diabetes(OR=0.11,95% CI0.033-0.368,P=0.000).There was no significant correlation with smoking,hypertension and high density lipoprotein(P>0.05).The severity of microhemorrhage was further analyzed by multiple Logistic regression,and the results showed that serum α-conuclein was not related to the severity of microhemorrhage(P>0.05).Subgroup analysis based on anatomical site showed that there were only differences in age and homocysteine among the groups(P<0.05).Conclusion:α-synuclein in serum was correlated with the occurrence of cerebral microbleeds,but not with the severity of cerebral microbleeds. |
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