| Background and Objective:Patients with acute cerebral infarction were examined by magnetic sensitivity weighted imaging(susceptibility-weighted imaging,SWI)sequence.the number and distribution of(cerebral microbleeds,CMBs)in patients with cerebral microhemorrhage were observed.combined with their clinical data,the relationship between the number of microhemorrhage and blood lipid was analyzed.In order to explore the clinical application value of microhemorrhage in the prevention and treatment of cerebrovascular diseases,and has acertain clinical significance for the control of blood lipid.Materials and methods:General data: patients with cerebrovascular disease treated in our hospital(affiliated Hospital of Taishan Medical College)from December 2017 to January 2019 were selected.patients with intracranial hemorrhage,space occupying,vascular malformation and other diseases were excluded.Finally,84 patients with acute cerebral infarction were included,and their detailed clinical data,including age,sex,smoking history,drinking history,hypertension history,diabetes history,etc.,were obtained with the informed consent of the patients.According to the magnetic sensitivity weighted imaging of MRI with or without microhemorrhage on(SWI),84 cases were divided into two groups: microhemorrhage group(n=36)and non-microhemorrhage group(n=48).The general clinical data and biochemical indexes of the two groups were compared,and the difference was evaluated by calculation,and the risk factors affecting the occurrence of cerebral infarction microhemorrhage were further analyzed.Equipment and examination methods: MRI was performed in patients with acute cerebral infarction.GE Discovery MR750 3.0T superconducting magnetic resonance scanner and 8-channel HEAD-A coil were used.SUN workstation(software version Advantage Workstation4.6)was used to scan the patients with TIW1,T2 WI PROPELLER,T2 WI FLAIR,DWI and SWI sequences.The number and location of microhemorrhage on SWI sequence were record-ed.The risk factors of microhemorrhage were analyzed by cross-sectional analysis.The patients were divided into two groups according to the presence or absence of micro-bleeding.the demographic data,past medical history,medication before admission and laboratory examination were compared between the two groups,and the related risk factors of microhemorrhage were further analyzed.Image evaluation: the signal characteristics,quantity and distribution of TIW1,T2 WI PROPELLER,T2 WI FLAIR,DWI and SWI sequences of each patient were recorded by the double blind method of two doctors with intermediate professional title or above,and the signal characteristics,quantity and distribution of MRI,MRI and MRI sequences were recorded,and the signal characteristics,quantity and distribution of MRI,MRI and MRI sequences were recorded respectively.At the same time,reference was made to the microhemorrhage observer scale(BOMBS)to improve the consistency among different researchers;after consensus,the number and distribution of microhemorrhage were recorded.Statistical data processing: the data collected above were analyzed by SPSS software and univariate analysis was used to screen the suspicious risk factors of microhemorrhage.Taking the presence or absence of microhemorrhage as the dependent variable and the related factors of P<0.05 as the independent variable,stepwise logistic regression analysis was carried out.the results showed that there was significant difference between the two groups(P<0.05).Outcome:1.There was no significant difference in age,sex,smoking,drinking,hypertension,diabetes and other general data between the two groups(P>0.05).2.Compared with the non-microhemorrhage group,the high density lipoprotein in the microhemorrhage group was significantly higher than that in the non-microhemorrhage group(P<0.01,P<0.05).There was no significant difference in other biochemical indexes between the two groups(P>0.05).3.The high density lipoprotein was divided into quartiles,and the concentration was calculated.the number of microhemorrhage under different quartiles was calculated,and the number increased gradually with the different percentiles of high density lipoprotein.4.The concentration of HDL-lt;25 percentile may be the protective factor of cerebral microhemorrhage,and the concentration of HDL-gt;75 percentile may be the risk factor of cerebral microhemorrhage.Conclusion:the number of microhemorrhage in patients with acute cerebral infarction is high.serum high density lipoprotein is a risk factor for microhemorrhage,and the high value of high density lipoprotein is an important risk factor for microhemorrhage. |
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