| Objective:Through the small airway lung function and the level of serum inflammatory factors,the effects of tobacco dependence and smoking cessation intervention on the small airway function and serum inflammatory factors of smokers without respiratory symptoms are discussed,so as to early intervention and improve the prognosis of smokers.Methods:1.69 smokers who visited the smoking cessation clinic of our hospital from May 2018 to December 2020 were included,the general information were collected,and exhaled carbon monoxide testing,lung function testing,and assessment of tobacco dependence were completed.2.To determine the smoking cessation day.Follow-ups will be conducted in the first week,second week,fourth week,and 12 th week after the smoking cessation day.At each follow-up,the patient’s smoking cessation status,drug use,adverse drug reactions,withdrawal symptoms,and nicotine evaluation should be asked and the tobacco dependence were evaluated.Exhaled carbon monoxide levels should be tested at the first week,fourth week,and 12 th week.After the 12 weeks of follow-up,the subjects’ withdrawal status will be assessed.Subjects who have been abstained for 3 months without smoking and exhaled carbon monoxide <6ppb will be chosed to collect Specimen and complete lung function testing again.3.The serum levels of IL-6,IL-8,IL-10,and CRP were detected by ELISA.4.Use SPSS25 software to organize and analyze the data,compare the small airway function and IL-6,IL-8,IL-10,CRP levels in serum at the time of enrollment and3 months after complete cessation of smoking.P<0.05 were statistically significant.Results:1.A total of 69 subjects who met the enrollment conditions were included in the study.27 subjects were willing to take peripheral blood samples.After the follow-up,10 subjects who had been abstained for 3 months without smoking were willing to undergo pulmonary function tests.5 subjects who had been abstaining for 3 months without smoking were willing to take blood samples again;2.A comparative analysis of lung function at the beginning found that the MMEF level of smokers was lower than that of the normal control group(p<0.05),the age of the moderate and heavy smoking group was higher than that of the light smoking group,and the age of the heavy smoking group was higher than that of the normal control group,The differences were statistically significant(p<0.05).The FEF75 of the heavy smoking group was lower than that of the light dependent group,and the difference was statistically significant(p<0.05).The MMEF of the heavy smoking group was lower than that of the normal control group,and the difference was statistically significant(p<0.05).Age,smoking time,daily smoking and smoking index were negatively correlated with FEF75 and MMEF(p<0.05).Small airway function did not improve significantly after quitting smoking.3.A comparative analysis of serum inflammation at the beginning found that the level of IL-8 in smokers was higher than that in the normal control group,the level of IL-8 in the small airway dysfunction group was higher than that in the normal control group,and the level of IL-8 in the smoking group with normal lung function was higher than that of the normal control High(P<0.05),IL-8 level is negatively correlated with FEF75%pred,the higher the IL-8 level,the lower the FEF75%pred value.There was no significant improvement in serum inflammation after smoking cessation.Conclusion:1.Smokers’ small airway function indicators decreased,but after short-term smoking cessation intervention for 3 months,the small airway function did not improve significantly;2.Smokers,especially those with small airway dysfunction,increased IL-8 secretion,and IL-8 was related to lung function This may be the cause of the further deterioration of small airway function and airway inflammation in smokers. |
PDF Full Text Request