| Objective: By comparing the postoperative complications and clinical efficacy of MRI-guided argon-helium cryoablation and surgical treatment in elderly lung cancer patients,this article investigates the safety and effectiveness of MRI-guided argon-helium cryoablation in elderly lung cancer patients.Methods: A retrospective study was conducted to analyze the clinical data of 28 elderly patients with NSCLC who underwent MRI-guided argon-helium cryoablation and 28 elderly patients with NSCLC who received video-assisted thoracic surgery(VATS).This article analyzes the improvement of Karnofsky functional status(KPS),pulmonary function changes as well as imaging changes between patients before and after cryoablation and patients before and after VAST,counts their complications and tracks the survival time and survival rates of patients after cryoablation.Results:1.The improvement of Karnofsky functional status scale.The results showed that the experimental group had effective rate of 92.9%.In the control group,the effective rate was 67.9%(19/28).The effective rate of the two groups was significantly different(P < 0.05),considering that the effective rate of the experimental group was higher than that of the control group.2.Lung functionThe results showed that FEV1 before and one week after the surgery in the experimental group was(2.12±0.31)and(2.13±0.35)respectively.FEV1 before and 1 week after operation was(2.16±0.39)and(1.58±0.28);The FEV1/FVC values of experimental group before and 1 week after operation were(69.92±11.96)% and(70.77±11.88)%,respectively.The FEV1/FVC of the control group before and one week after operation were(70.87±10.06)% and(64.19±9.73)%,respectively.There was slight difference in FEV1 and FEV1/FVC between the two groups(P >,0.05).There was no significant difference between FEV1 and FEV1/FVC in the experimental group(P >,0.05)as well.In the control group,FEV1 and FEV1/FVC were lower after operation than before(P < 0.05).The postoperative lung function of the experimental group was significantly better than that of the control group,with significant difference between the two groups(P < 0.05).3.Operation time and complicationsOperation time of patients in 2 groups was counted,and incidence of infection,pneumothorax and atelectasis was compared between the two groups.The results showed that the operation time of the experimental group and the control group was(97.61±17.21)and(144.85±22.99),respectively.There were no postoperative infection patients and postoperative atelectasis patients in the experimental group,and the incidence of pneumothorax was 7.1%.The incidence of infection in the control group was 7.1%,3.5% of pneumothorax,and 10.7% of atelectasis.The operation time of the experimental group was significantly less than that of the control group,which was significantly different between the two groups(P < 0.05),while the incidence of postoperative infection,pneumothorax and atelectasis had no significant difference between the two groups(P >0.05).4.Survival rate and recurrence rateThe survival rates of the experimental group and the control group were 92.9% and96.4%,respectively.The recurrence rates of the experimental group and control group were10.7% and 14.3%,respectively.There was no significant difference in survival rate and recurrence rate between the two groups(P >0.05).5.Response Evaluation Criteria In Solid TumorsThe results showed that the CR in the experimental group was 0%,PR was 25.0%,SD was 60.7%,PD was 14.3%,the effective rate was 25%,and the control rate was 83.3%.Conclusion:1.MRI-guided argon-helium cryoablation technology has advantages of small surgical injury,minor complications and good tolerance of elderly patients and so on,and it is safe and feasible.Therefore it is worthy to further study and be widely applied in clinical practice.2.MRI-guided argon-helium cryoablation can delay tumor progression as well as improve patients’ life quality. |
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