The Influence Of Sirpα Deletion In Microglia On The Pathological Process Of Alzheimer

Microglia play a key role in regulating synaptic remodeling in the central nervous system.In the process of development and disease,the activation of the classical complement pathway promotes the pruning of synapses mediated by microglia,and the CD47 of neurons protect synapses from being over-pruned.Our previous results show that neuronal CD47 and microglia SIRPα combine to generate inhibitory signals that guide microglia to recognize synapses that need to be preserved.However,the changes and effects of SIRPα signaling in synaptic pathology-related diseases(Alzheimer’s disease,AD)have not been studied yet.We use microglial SIRPα-specific knockout mice,combined with AD mouse models,to systematically study the influence and effect of microglial SIRPα signal changes on the pathological process of adult AD.The results of the study showed that the expression of SIRPα in microglia decreased significantly during the pathological process of AD,and the loss of SIRPα aggravated the loss of synapses and cognitive memory in AD mice.The above results suggest that the SIRPα signal of microglia may play an important role in the pathology of AD neurons.