Effect Of 0.01% Atropine Eye Drops On Ocular Accommodation And Related Biological Parameters In Myopic Children

Part I Effect of 0.5% compound topicamide eye drops on biological parameters of myopia in childrenObjective: To evaluate the effects of 0.5% compound topicamide eye drops on biological parameters of myopia in children before and after ciliary muscle paralysis.Methods: A total of 15 children(30 eyes)diagnosed with myopia in Hainan Eye Hospital from October 2020 to January 2021 were collected.IOL Master 700 and Pentacam were used to measure the biological parameters of the eyes before and after ciliary muscle paralysis with 0.5% compound topicamide eye drops.Results:1.IOL Master 700 measurements showed that after the use of 0.5% compound topicamide eye drops to paralyse the ciliary muscle,AL increased 0.001±0.036 mm compared with before,and the difference was not statistically significant(P>0.05);ACD increased by 0.079±0.050 mm,AQD increased by0.068±0.051 mm,LT decreased by 0.047±0.057 mm,KM decreased by 0.040±0.095 D,CCT increased by 9.667±6.216 um,and the difference was statistically significant(P<0.05).2.Pentacam measurement showed that the anterior chamber volume increased by2.400±21.175mm3 and KM increased by 0.010±0.103 D after parciliary muscle paralysis with 0.5% compound topicamide eye drops,and the difference was not statistically significant(P>0.05);Corneal volume increased by 0.590±0.477mm3,anterior chamber depth increased by 0.045±0.052 mm,and the difference was statistically significant(P&L;0.05).Conclusion:The effect of 0.5% compound topicamide eye drops on ocular biological parameters such as anterior chamber depth,lens thickness,corneal thickness,corneal volume and so on was significant.Part II: Effect of 0.01% atropine eye drops on ocular accommodation and related biological parameters in myopic childrenObjective: To evaluate the effects of 0.01% atropine eye drops on ocular accommodation and related biological parameters in myopic children after 1 month of administration.Methods: A prospective randomized controlled study was conducted.Thirty-five children diagnosed with myopia in Hainan Eye Hospital from July 2020 to January2021 were collected and randomly divided into the experimental group and the control group.The experimental group(22 cases)had 1 drop of 0.01% atropine sulfate eye drop at each point of eyes before bed,while the control group(13 cases)had 1 drop of sodium hyaluronate eye drop at each point of eyes before bed.The children in both groups were followed up for 1 month,and the changes of amplitude of regulation(AMP),sensitivity of regulation(AF),relative regulation of positive and negative(NRA,PRA),AC/A,stereoscopic vision,refraction,ocular axis(AL),anterior chamber depth(ACD),lens thickness,pupil diameter,intraocular pressure and symptoms in both groups were recorded before,1 week and 1 month after treatment.Results:1.AMP was 10.63 3.13 10.64 3.43 11.05 2.59 D in experimental group and 9.913.68 10.59 3.11 10.56 2.06 D in control group,respectively,after 1 week and 1month of treatment before treatment.12.88 2.94 13.00 2.66 14.00 2.56 CPM in the trial group and 12.88 2.94 13.00 2.66 14.00 2.56 CPM in the control group;They were 2.61 0.71 3.06 1.10 2.98 0.82 D in the NRA experimental group and 2.59 0.68 2.63 0.79 2.56 0.4D in the control group,respectively.PRA test group were 2.590.68 2.63 0.79 2.56 0.4D,and control group were-2.06 1.22-2.31 0.96-2.78 0.73 D,respectively.AC/A were-2.06 1.22-2.31 0.96-2.78 0.73 in the experimental group and 3.94 2.04 4.31 2.28 4.69 1.79 in the control group,respectively.Stereo vision in the experimental group was 40,40,and in the control group was 81.5,50,45,respectively.There was no statistically significant difference in the above eye regulation indexes between the two groups at each time point,nor was there any statistical significance between the two groups.2.In the experimental group,the anterior chamber depth was 3.68 0.27 3.67 0.283.65 0.28 mm in the experimental group and 3.76 0.17 3.73 0.2 3.73 0.19 mm in the control group after 1 week and 1 month of treatment before treatment.The lens thickness of the experimental group was 3.34 0.12 3.36 0.16 3.38 0.17 mm,and that of the control group was 3.35 0.08 3.36 0.07 3.37 0.09 mm,respectively.The IOP of the experimental group was 17.38 1.67 16.44 1.83 16.81 2.69 mm Hg,and that of the control group was 17.38 2.77 16.75 0.89 17.25 1.39 mm Hg,respectively.There was no statistically significant difference in the above biological parameters between the two groups at each time point,nor was there any statistically significant difference between the two groups.3.After 1 week of treatment,the mean pupil diameter in experimental groups increased by 0.48 compared with that before treatment,respectively,the difference was statistically significant.In the experimental group,the diameters of dark pupils were 6.56 0.87 6.64 0.85 6.66 0.85 mm,respectively,1 week before treatment and 1month after treatment.In the experimental group,the diameters of bright pupils were 3.36 1.25 3.54 1.75 4.13 1.20 mm,respectively,dark There was no significant difference in bright pupil diameter at each time point.4.1 week before treatment and 1 month after treatment in the experimental group,the diopter values in the experimental group were-1.98 1.38-1.95 1.37-2.05 1.44 D and-1.69 1.14-1.72 1.17-1.78 1.24 D in the control group,respectively.The AL test group was 24.3 0.95 24.31 0.94 24.35 0.95 mm,and the control group was 24.30.84 24.32 0.85 24.34 0.87 mm,respectively.There was no significant difference in the diopter and axis between the two groups at each time point.After 1 month of treatment,1 case(4.5%)of children in the experimental group had blurred vision which affected their learning during the day,and the symptoms disappeared after drug withdrawal;1 case(4.5%)had systemic rash after drug withdrawal for 1 month,and 2 cases(9%)had mild photophobia,which did not affect their vision,and had no discomfort to indoor light.Conclusion:1.The use of 0.01% atropine eye drops has little effect on eye regulation and related biological parameters,with high safety.2.The effect of 0.01% atropine eye drops on the refraction and axis of the eye needs to be observed for a longer time to judge the efficacy.