Based On Data Mining Technology To Discuss The Rule Of Professor Zhou Xiaoli’s Treatment Of Thalamic Pain In Convalescent Stage Of Ischemic Stroke

Objective:Through the data mining technology,the author preliminarily discusses and summarizes professor Zhou Xiaoli’s medication law and diagnosis and treatment experience in treating patients with thalamic pain in recovery stage of stroke,to summarize,absorb and inherit professor Zhou Xiaoli’s clinical diagnosis and treatment thinking and academic thought,to provide reference for the treatment of thalamic pain in convalescence of stroke.Methods:The data of patients with thalamic pain in the convalescent period of stroke who were hospitalized in the First Department of Encephalopathy,Hubei Provincial Hospital of Traditional Chinese Medicine（Huayuanshan District）from October 2017 to December 2021 and who took Professor Zhou Xiaoli’s syndrome-differentiated Chinese herbal formula were collected.According to the diagnostic criteria,inclusion criteria and exclusion criteria,72 patients were screened.A total of 195 prescriptions were collected and 184 flavors of traditional Chinese medicine were used.The basic information of patients and traditional Chinese medicine prescriptions were imported into Microsoft Office Excel 2019 form to establish an original database for data cleaning,standardization,Sort out and perform frequency analysis to summarize high-frequency traditional Chinese medicines,and conduct frequency analysis on the properties and taste of all medicines;continue to import high-frequency medicines into IBM SPSS Molder18.0,Cytoscape 3.8 for association rule analysis,and import into IBM SPSS Statistics 20.0 for analysis Cluster analysis and factor analysis,and finally summed up the high-frequency drug combination and traditional Chinese medicine treatment method,and summarized Professor Zhou Xiaoli’s academic thoughts on the treatment of thalamic pain in the convalescent period of stroke.Results:A total of 184 traditional Chinese medicines were included in this study,and the total frequency of use was 3353.Among them,there were 50 high-frequency traditional Chinese medicines.The top ten were Chuanxiong,Angelica,Licorice,Poria,Astragalus,Dilong,Atractylodes,Baishao,Pinellia,and Achyranthes.,2625 times of high-frequency drugs were used,accounting for 78.29% of the total drug frequency;the total drugs belonged to 14 categories,mainly tonic drugs,blood-activating and stasis-removing drugs,liverpacifying and wind-relieving drugs,and wind-dampness drugs,among which tonic drugs mainly The medicines are qi-tonifying and bloodtonifying medicines.The medicines for promoting blood circulation and removing blood stasis are mainly medicines for promoting blood circulation and regulating menstruation and relieving pain.The medicinal properties are mainly warm,flat and slightly cold;the medicinal tastes are mainly sweet,pungent and bitter,with a cumulative frequency of 79.36%;The main meridians entered are liver meridian,spleen meridian,lung meridian,and heart meridian,with a cumulative frequency of 68.12%;high-frequency drug association rules obtained 2 binomial associations in drug pairs（groups）,which are Dilong-Zongshen,Tianma-gou Rattan,19 of the three associations,21 of the four associations,the strongest association among the three associations is safflower-peach kerneldilong,and the strongest association among the four associations is peach kernel,safflower-licorice-chuanxiong;complex network diagram It is suggested that Astragalus,Angelica,Chuanxiong,Poria,Pinellia,Atractylodes,Dilong and Licorice are the core drug groups;a total of 8 groups of drug combinations were obtained by high-frequency traditional Chinese medicine clustering,including: C1: keel,oyster,Suanzaoren,Bupleurum,Scutellaria baicalensis,Gardenia,Corydalis,Cyperus officinalis;C2:Gastrodia elata,Uncaria,Rehmannia glutinosa,Ophiopogon japonicus,Chinese yam,Alisma,Cortex Moutan;C3: Dilong,Silkworm,Quan Scorpion,Mulberry Branch,Salvia;C4: Polygala,Shichangpu,Turmeric,Atractylodes,Dannanxing,Chenpi,Pinellia,Zhuru,Citrus,Licorice,Coptidis;C5: Angelica,Red Peony,Peach Kernel,Safflower,Chuanxiong,Astragalus;C6: White Peony,Guizhi,Chickweed,Pueraria,Coix Seed;C7: Papaya,Turmeric,Honeysuckle;C8: Achyranthes,Eucommia,Wei Lingxian.High-frequency drug factor analysis obtained 20 public factors.The treatment methods include supplementing and reducing,regulating qi and strengthening the spleen,drying dampness and resolving phlegm;removing phlegm and opening orifices,soothing the mind and calming the mind;Dispelling wind and dispelling dampness;clearing heat and cooling blood,promoting blood circulation and removing blood stasis;calming liver-yang,promoting qi and relieving depression,etc.Conclusion:1.Astragalus,Angelica,Chuanxiong,Poria,Pinellia,Atractylodes,Dilong and Licorice are the core drugs used by Professor Zhou Xiaoli to treat patients with thalamic pain in convalescent stroke;,Licorice,peach kernel,safflower,Astragalus,Dilong,Chuanxiong,Angelica,Rehmannia glutinosa,Ophiopogon japonicus,Chinese yam,Alisma,Cortex Moutan,keel,oyster,Suanzao Ren,Bupleurum,Scutellaria baicalensis,Gardenia,Corydalis,Cyperus officinalis,Yuanzhi,Shichangpu,Turmeric,Atractylodes,Dannanxing,tangerine peel,Pinellia,Bamboo Ru,Citrus,Poria,Licorice,Coptidis,Paeonia lactiflora,Guizhi,Chixueteng,Pueraria,Coix Seed,Papaya,Turmeric,Honeysuckle vine,Achyranthes,Eucommia ulmoides,Wei Lingxian are commonly used drug combinations;Replenishing and reducing and applying,dampness and phlegm;Dispelling wind and dispelling dampness;clearing heat and cooling blood,promoting blood circulation and removing blood stasis;calming liver-yang,promoting qi and relieving depression are the main treatment methods;the core prescription is: Astragalus 20 g,Angelica 10 g,Chuanxiong 15 g,Baishao 30 g,dried tangerine peel 10 g,half of the method Xia 10 g,Poria 15 g,Gastrodia elata 15 g,Uncaria 15 g,Corydalis 10 g,Scarlet vine 30 g,Honeysuckle vine 20 g,Achyranthes 15 g,Salvia 20 g,Shichangpu 20 g,Suanzaoren 30 g,Jiaoshan Hawthorn 10 g,Silkworm10g,Whole scorpion 10 g,Dilong 10 g,Licorice 10 g.Throughout the whole prescription,Master Zhou’s prescription for treating thalamic pain in the convalescent period of stroke can be divided into three aspects:（1）Treating from qi and blood,nourishing qi and nourishing blood,invigorating the spleen and stomach,and treating the disease from the root;（2）Mainly focus on promoting blood circulation,removing blood stasis and relieving pain,combined with the treatment methods such as relieving wind and relieving spasm,removing phlegm and resolving turbidity,clearing heat and dredging collaterals,eliminating vexation and soothing the nerves;2.Deficiency of righteous qi and occlusion of meridians are the pathogenesis of thalamic pain in the convalescent period of stroke.The disease location is in the brain orifice.Phlegm turbidity,blood stasis,qi stagnation,stagnation of heat,internal wind,etc.are the key pathological factors.,if it doesn’t work,it will pass or suffer from disgrace.Strengthening the righteousness and eliminating pathogenic factors,promoting blood circulation and removing blood stasis,dredging collaterals and relieving pain throughout the whole process;at the same time taking into account other pathogens,removing phlegm,dispersing knots,clearing heat,reducing dampness,and expelling wind and other methods;Paying attention to sleep and rational use of insect drugs are the diagnosis and treatment ideas of Professor Zhou Xiaoli in the treatment of patients with thalamic pain in the convalescent period of stroke.