Clinical Observation Of Lingdan Tablet Combined With 308nm Ultraviolet Light In The Treatment Of Alopecia Areata

Objective:To observe the clinical efficacy and safety of Lingdan tablet combined with 308 nm ultraviolet light in the treatment of alopecia areata,and to provide therapeutic reference for clinical safety and effective treatment of alopecia areata.Method:Alopecia areata patients who met the inclusion and exclusion criteria of this clinical observation study were collected from the dermatology department of the First Hospital of Wuhan,and the collected patients were randomly divided into observation group and control group.Both groups were treated with 308 nm UV phototherapy in the skin lesion area,once a week.The control group was treated with halometasone cream in the hair loss area on the basis of phototherapy,twice a day,thin coating and massage absorption.Observation group on the basis of phototherapy combined with Lingdan tablets orally,3 tablets each time,3 times a day;The total treatment duration was 12 weeks.Skin quality of life score,changes of end hair density under dermatoscopy,adverse reactions during treatment and gross hair growth in skin lesions were observed and recorded in 2 groups before and after treatment.Statistical software（SPSS 25.0）was used to analyze the relevant data to evaluate the clinical efficacy and safety.Consequence:1.Baseline dataIndependent sample T-test showed no significant difference in age distribution between the two groups（P > 0.05）.Chi-square test showed no significant difference in gender distribution between the two groups（P > 0.05）.Independent sample T test showed no significant difference in the course of disease between the two groups（P > 0.05）.All subjects included in this study had mild alopecia areata with no difference in disease severity.It can be seen from the above that the 61 subjects eventually included in this clinical observation study showed no statistical difference in the baseline data of age,gender,disease course and disease grade,and the groups were comparable.2.Dermatology life quality indexIndependent sample T-test showed that there was no significant difference in quality of life index between the two groups before treatment（P > 0.05）,indicating comparability between the two groups.There was statistical difference in quality of life index between the two groups before and after treatment（P < 0.05）.After 12 weeks of treatment,the quality of life index of the two groups and the intra-group quality of life index before and after treatment were statistically significant（P < 0.05）;The results indicated that the decline degree of skin disease quality index in the observation group was better than that in the control group.3.Results of visual evaluation of curative effectIn the observation group of 30 patients,9 cases were cured,10 cases were effective,7 cases were effective and 4 cases were ineffective,with a total effective rate of 86.67%.In the control group of 31 patients,6 cases were cured,12 cases were effective,4 cases were effective and 9 cases were ineffective,the total effective rate was 70.96%.There was statistical difference（P < 0.05）,indicating that the gross clinical efficacy of the observation group was better than that of the control group.4.Dermoscopic terminal hair densityBefore treatment,there was no statistical difference in terminal hair density between the two groups（P > 0.05）,which was comparable between the two groups.There was statistical difference in terminal hair density between the two groups before and after treatment（P < 0.05）.There were statistically significant differences in terminal hair density between the two groups after 12 weeks of treatment and within the two groups before and after treatment（P < 0.05）,suggesting that the hair growth in the observation group was better than that in the control group.5.Incidence of adverse reactionsAmong the 61 patients included in this study,1 patient in the observation group showed redness,swelling and pruritus in the irradiation area after phototherapy,while the rest of the patients did not have obvious adverse reactions.The incidence of adverse reactions was 3.33% in the observation group and 0%in the control group,and there was no significant difference between the two groups（P > 0.05）.Conclusion:The clinical efficacy of Lingdan tablet combined with 308 nm ultraviolet light therapy in the treatment of alopecia areata is superior to conventional treatment,especially in improving the quality of life of alopecia areata patients and promoting hair growth,and the safety is good,worthy of clinical promotion.