Study On The Mechanism Of 16 Week Taijiquan Exercise On Atherosclerosis In Middle-aged And Elderly People

Objective:This paper carried out 16 weeks of Taijiquan exercise intervention on people with AS,observed the changes of baPWV blood lipid level,inflammatory factors and other related indicators of subjects after 16 weeks of exercise intervention,analyzed the prevention and treatment effect of Taijiquan Exercise on people with arteriosclerosis,nd explored the influence mechanism of Taijiquan Exercise on reducing arterial stiffness and delaying atherosclerosis,to provide a theoretical basis for the intervention research of cardiovascular diseases.Methods:In this study,46 people（10 males and 36 females）with abnormal arterial stiffness were selected from Lanyuan community,with an average age of 52.41 ± 2.30 years.Combined with the willingness to exercise,they were randomly divided into exercise group and non exercise control group,including 26 in exercise group and 20 in non exercise control group.Before the intervention,the bull’s-eye rate of each subject in exercise group was measured by power bicycle,and 5 days/week,1h/day moderate intensity Taijiquan exercise intervention;In addition to controlling exercise,the control group carried out normal daily life.The height,weight,body fat rate,baPWV,ABI and other physiological indexes of the subjects were measured before the experiment and at the end of 16 weeks of experimental intervention;LDL-R and blood lipids（TG,TC,LDL-C,HDL-C）,inflammatory factors（MCP-1,VCAM-1,PPARγ）and IMA and other biochemical indexes.Results:（1）Before the experiment,the exercise group and the control group were homogeneous.（2）Compared with that before exercise,the body weight and body fat of the exercise group decreased significantly at the end of 16 weeks（P<0.05）,indicating that Taijiquan exercise has a significant effect on reducing fat in patients with abnormal arteriosclerosis.（3）Compared with before exercise,the ima content and baPWV of left and right sides in the exercise group decreased significantly at the end of 16 weeks after Taijiquan exercise intervention（P<0.05）,and ABI decreased（P>0.05）,but there was no significant difference.The serum ima content in the control group increased slightly.（4）Compared with before exercise,the contents of serum TC and LDL in the exercise group decreased significantly at the end of the 16th week of exercise（P<0.05）,and the contents of serum HDL and LDL-R increased significantly（P<0.01）;There was no significant difference between the control group before and after the experiment.（5）Compared with before exercise,at the end of the 16th week of exercise,the levels of serum MCP-1 and VCAM-1 in the exercise group were significantly lower（P<0.05）,and the levels of serum PPARγ increased significantly（P<0.05）;There was no significant difference in the control group before and after the experiment.Conclusions:（1）After 16 weeks of Taijiquan exercise,the levels of baPWV and IMA in the middle-aged and elderly with abnormal arterial stiffness decreased significantly.Taijiquan exercise can be used as an effective means of prevention and treatment of as.（2）After 16 weeks of Taijiquan exercise,the fat rate of middle-aged and elderly people decreased significantly,and the level of LDL-R increased significantly;Therefore,Taijiquan exercise can significantly improve the blood lipid status of middle-aged and elderly people with abnormal arterial stiffness;The regulation of dyslipidemia may be a maj or mechanism of Taijiquan in the prevention and treatment of as.（3）After 16 weeks of Taijiquan exercise,the levels of baPWV and IMA in the middle-aged and elderly with abnormal arterial stiffness decreased significantly.Taijiquan exercise can be used as an effective means of prevention and treatment of as.After 16 weeks of Taijiquan exercise,the levels of serum inflammatory factors（MCP-1,VCAM-1）decreased significantly,and anti-inflammatory factor（PPARγ）The level increased significantly,indicating that Taijiquan exercise can effectively alleviate the serum inflammatory level of middle-aged and elderly people with abnormal arterial stiffness.The improvement of inflammatory level may be another mechanism of Taijiquan exercise in the prevention and treatment of as.