| Objective:Observe underwent emergency percutaneous coronary intervention(PCI)in patients with acute myocardial infarction(AMI)through sand used in kubah valsartan(ARNI)on its cardiac remodeling and cardiac function after treatment,research and analyze ARNI the anticipated benefit for the patients,and to explore the treatment of these patients and put forward new ideas.Methods:This study in strict accordance with the inclusion criteria and exclusion criteria collected from January 2020 to June 2020 in the first affiliated hospital of xinjiang medical university cardiovascular intensive care unit for emergency PCI operation,a total of 80 patients with AMI and randomly divided into research group and the control group,40 cases in each group,and collecting the basic data and clinical related information,First,conventional drug therapy was given.On this basis,ARNI and benazepril hydrochloride were respectively given to the two groups.The general baseline data of the two groups were compared.The indexes of N-terminal B-type natriuretic peptide precursor(NT-pro BNP),troponin I(c Tn I),serum creatinine(Cr)and serum potassium(K~+)were monitored before and immediately after medication in 2 groups of patients during hospitalization,and the parameters obtained by cardiac ultrasound examination immediately after PCI were recorded:Left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-diastolic anteroposterior diameter(LVEDD),left ventricular end-systolic volume(LVESV),left ventricular end-systolic diameter(LVESD),Respectively,and two groups of patients after discharge of the first month,3 months,6 months follow-up for the biochemical and cardiac ultrasound examination,and perfect the Kansas city cardiomyopathy questionnaire(KCCQ)score,at the same time record of two groups of patients in hospitalization and adverse drug reactions occurring is a period of 6 months after discharge and major adverse cardiovascular events(MACE).RESULTS:There were no significant statistical differences between the two groups in general baseline data,biochemical serological indicators such as NT-pro BNP,c Tn I,Cr,K~+,and cardiac structural parameters such as LVEF,LVEDD,LVEDV,LVESD,LVESV at the time of inclusion(P>0.05).After treatment,the levels of NT-pro BNP,c Tn I,LVEDD,LVESD,LVESV and LVEDV in the two groups at 1,3 and 6 months were gradually decreased compared with before,while the LVEF value was significantly increased,with significant statistical difference within the group(P<0.05).There was a significant statistical difference in c Tn I level between the two groups at the first month after discharge(P<0.05),while there was no significant statistical difference in c Tn I level between the two groups at the third and sixth months after discharge(P>0.05).At 1,3 and 6months after discharge,the measured levels of NT-pro BNP in the study group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the clinical data of Cr and K~+tests at 1,3 and 6 months after treatment and discharge(P>0.05).At the 1st month after hospitalization,the comparison of LVEF,LVEDD,LVESD,LVESV and LVEDV between the two groups showed no statistical difference(P>0.05),while at the 3rd and 6th month after hospitalization,the difference between the two groups was more significant(P<0.05).There were no significant differences in adverse drug reactions and MACE events between the two groups within 6months(P>0.05).CONCLUSIONS:By comparing benazepil hydrochloride,it has been confirmed that ARNI can significantly improve cardiac function in patients with AMI who underwent emergency PCI,inhibit cardiac remodeling function,and have better effect on preventing the occurrence of heart failure and early clinical treatment in patients with myocardial infarction,and the incidence of MACE events and adverse drug reactions is low. |
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