Photothermal Therapy Control Method For Tumor Temperature Measurement And Research On Photoacoustic

With the development of human society,malignant tumors have gradually become the primary threat to human life and health.Therefore,early dia gnosis and early treatment of tumors are particularly important.Emerging medical technologies continue to emerge with the development of science and technology.As a new green tumor therapy,photothermal therapy has become a research hotspot in tumor treatment due to its advantages of safety,non-radiation,and targeting.However,the lack of practically usable non-invasive temperature detection methods and closed-loop temperature control methods in the existing photothermal therapy will not only increase the difficulty of treatment,but also cause over-treatment or under-treatment.As a new technology that combines the advantages of optics and acoustics,photoacoustic technology stands out among the existing medical testing methods.Photoacoustic technology has the characteristics of cross-scale,high resolution,and non-radiation,which provides a new idea for cancer diagnosis and treatment.This subject proposes a non-invasive temperature detection method suitable for tumor photothermal therapy and a temperature control method during the treatment process,including the design and implementation of the software and hardware of a single-element photoacoustic photothermal system,and a noninvasive temperature measurement method based on photoacoustic signals and the matching temperature control method.The main contents are as follows:First,the photoacoustic temperature measurement method is studied.The principle of laser ultrasound and the propagation and reception of photoacoustic signals are analyzed in detail.On this basis,the correlation between photoacoustic signal and temperature is studied,and the reason why photoacoustic technology can be used as a non-invasive temperature measurement method is discussed.Make full use of the effective temperature information of the photoacoustic signal to study the temperature measurement accuracy improvement strategy to achieve high-precision non-invasive temperature measurement.Secondly,a single-element photoacoustic and photothermal system was designed and built.For different functional applications,the system host computer control program and human-computer interaction interface are written to realize the photoacoustic temperature measurement function,temperature imaging function and temperature control function.It ensures the practicability of the system and provides powerful system support for the photothermal treatment of tumors.Then,perform finite element analysis for tumor photothermal therapy,including light transmission,heat conduction and thermal damage,and determine the laser irradiance and irradiation time required for photothermal therapy based on the analysis results.The mathematical model of the system is established and simplified,and the feasibility of the control scheme is verified through simulation in combination with the actual system parameters.Finally,experimental verification,design the temperature measurement,temperature imaging and temperature control performance of the simulated body and the in vitro experimental test sy stem.The photoacoustic temperature measurement and temperature control combined with the existing indicators are analyzed in detail,and the advantages of this method compared with other methods are explained,and it is believed that it can be extended to the clinic.This subject completed the work of system implementation,method research and software development to experimental verification.The single-element photoacoustic photothermal system elaborated and verified the accuracy of photoacoustic non-invasive temperature measurement and temperature imaging.The closed-loop temperature control scheme also made up for the technical shortcomings of open-loop treatment in clinical practice.It improves the accuracy of treatment and reduces the operational complexity of medical staff,and promotes the clinical transformation process of the integration of photoacoustic,p hotothermal diagnosis and treatment.