Clinical Observation The Therapeutic Effect Of Pang’s 3+5 Plan In The Treatment Of Perimenopausal Damp-heat Stasis Type During The Period Of Acute Menstrual Bleeding

Purpose: This topic will compare the therapeutic effect of the treatment group using Pang’s 3+5 regimen and the control group of oral Gongxuening Capsule on the treatment of perimenopausal and metrorrhagia with damp-heat and stasis type,and objectively evaluate the difference in curative effect between the two groups to prove that The effect of Pang’s 3+5 plan in treating collapse and hemostasis reveals its mechanism of action and provides new ideas and methods for clinical treatment of this disease.Method: From January 1,2020 to December 1,2020,66 patients with perimenopausal and metrorrhagia who met the inclusion criteria and volunteered to participate in the subject were selected for treatment at the gynecological outpatient department of the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine.Using random number table method,they were divided into treatment group and control group with 33 cases each.Patients in the treatment group were treated with Pang’s 3+5 plan,and patients in the control group were treated with Gongxuening Capsules orally.The observation course of treatment in both groups was10 days.Observe the hemostatic effect,total effective rate,TCM syndrome integral,endometrial condition and changes of prothrombin time(PT)and activated partial thromboplastin time(APTT)in the two groups.Result:1.Hemostatic effect: The hemostatic effect was 87.5% in the treatment group and70.97% in the control group(P<0.05),indicating that the hemostatic effect of Pang’s3+5 regimen was better than that of Gongxuening capsule..2.The total effective rate was 84.38% in the treatment group and 67.74% in the control group(P < 0.05),indicating that the total effective rate of Pang’s 3+5 plan was better than that of Gongxuening capsule.3.TCM syndrome score: Comparison between the two groups: there were significant differences in the improvement of vaginal bleeding volume,bleeding days,menstrual blood smell,menstrual blood clot,mouth pain,abdominal pain,dry stool and other symptoms between the two groups(P<0.05).It shows that Pang’s 3+5 plan has more advantages in the treatment of the above seven TCM symptoms.4.Endometrial thickness: Compared within the group,there were significant differences in endometrial thickness between the two groups before and after treatment(P < 0.05),Indicating that both groups could reduce the endometrial thickness to a certain extent;Comparison between groups: there was significant difference in endometrial thickness between the treatment group and the control group after treatment(P < 0.05),indicating that Pang’s 3+5 plan was superior to Gongxuening capsule in reducing endometrial thickness.5.Comparison between PT and APTT: Intra-group comparison: there were significant differences in PT and APTT between the two groups before and after treatment,indicating that both groups could shorten the time of PT and APTT.Comparison between the two groups: the values of PT and APTT in the treatment group and the control group before and after treatment were significantly different(P< 0.05),indicating that Pang’s 3+5 plan was superior to Gongxuening capsule in shortening the time of PT and APTT.6.Safety index: the treatment group treated with Pang’s 3+5 plan and the control group treated with Gongxuening capsule were examined for safety before and after treatment,and there was no abnormality.Conclusion: Compared with Gongxuening capsule,Pang’s 3+5 plan can improve the hemostatic effect of peri-menopausal patients with metrorrhagia of dampness-heat stasis,improve the TCM syndrome,reduce the thickness of endometrium,shorten the time of PT and APTT,and there are no adverse reactions during the treatment,so it is safe and worthy of clinical application.