Clinical Observation Of Shugan Lipi Decoction In The Treatment Of Subclinical Hypothyroidism Of Hashimoto Type Of Liver Depression And Spleen Deficiency

Objective: To evaluate the scientific and effectiveness of Shugan Lipi Decoction in the treatment of Hashimoto’s Thyroiditis with Subclinical Hypothyroidism and the changes in relevant laboratory indicators and clinical symptoms after oral administration of Shugan Lipi Decoction in patients with the syndrome of stagnation of liver and deficiency of spleen.Methods: Seventy-two patients with Hashimoto’s Thyroiditis with Subclinical Hypothyroidism in the outpatient department of the Second Affiliated Hospital of Yunnan University of Traditional Chinese Medicine with syndrome of stagnation of liver and deficiency of spleen were selected.According to the principle of parallel control and randomization,the enrolled patients were divided into the experimental group and the control group(a total of two groups).Patients for liver and spleen decoction,the control group given levothyroxine sodium(excellent armour)treatment,two groups of patients are all taking medicine against the eight weeks in a row,and before treatment and 8 weeks after treatment respectively detect a work 7(TPOAb,TGAb,TSH,TT3,FT3,TT4,FT4) level,the TCM syndrome integral evaluation related evaluation parameters,such as,evaluate its clinical efficacy.Results: 1.Among the 72 enrolled patients,1 fell out in the test group and 2 in the control group,respectively.In the end,35 cases were enrolled in the test group and 34 cases were enrolled in the control group,69 cases were enrolled.2.Before treatment,there was no significant difference in age,gender and course of disease between the two groups(P > 0.05),and the comparison between the two groups was comparable.The comparison of thyroid function TPOAb,TGAb,TSH,TT3,TT4,FT3,FT4,scores of TCM syndromes and total scores of TCM syndromes between the two groups before treatment was comparable(P > 0.05).3.Comparison between the two groups after treatment:(1)Thyroid function: intra-group comparison showed that TSH levels in both experimental group and control group after treatment were significantly decreased compared with before treatment,with significant differences(P < 0.01);The levels of TPOAb and TGAb in the two groups after treatment were compared with those before treatment,and there was statistical significance in the test group(P < 0.01),while there was no statistical difference in the control group(P > 0.05).The levels of TT3,FT3,TT4 and FT4 in the two groups after treatment were not significantly improved compared with those before treatment,and there was no statistical significance in both groups(P>0.05).The levels of TPOAb and TGAb in the experimental group and the control group were statistically significant(P < 0.01).There was no significant difference in TSH,TT3,FT3,TT4 and FT4 among groups(P>0.05).(2)TCM syndromes: intra-group comparison showed that the total scores of TCM syndromes in both groups were improved after treatment compared with before treatment,with statistical difference(P<0.01);The improvement of syndromes in experimental group was significantly better than that in control group(P<0.01).(3)Comparison of scores of TCM syndromes and symptoms: intra-group comparison showed that scores of symptoms such as "irritability,hypochoric and rib pain,emotional depression,body burnout and fatigue" were improved between the two groups compared with those before treatment,with statistical significance(P < 0.05);Compared with the control group,the experimental group was better than the control group in improving various TCM syndromes and symptoms,with statistical difference(P < 0.05).(4)Overall efficacy comparison: the total effective rate of the experimental group was 86%,and that of the control group was 54%.The results of the chi-square test between the two groups were of comparative significance(P < 0.01).Conclusion: Liver spleen decoction can effectively improve the Hashimoto Thyroiditis,and Subclinical Hypothyroidism syndrome differentiation of traditional Chinese medicine belong to change the patient’s clinical symptoms and their negative emotions,can effectively reduce the patient’s level of thyroid autoantibodies TPOAb,TGAb,and thyroid-stimulating hormone TSH level,especially in improving clinical symptoms and reduce has the apparent superiority of thyroid autoantibodies,for traditional Chinese medicine research accumulated some evidence-based evidence for the treatment of the disease.