Study On The Distribution Of TCM Syndromes Of Pulmonary Hypertension Associated With Systemic Lupus Erythematosus

ObjectiveThrough retrospective study,the data of inpatients with SLE-PAH admitted to our hospital from January 2000 to January 2021 were collected to explore the distribution law and clinical characteristics of TCM syndrome types of SLE-PAH,and provide the basis for clinical syndrome differentiation and treatment.MethodsThis study adopts the method of retrospective study,collected from January 2000 to January 2021 in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine in patients with SLE-PAH gender,age,course of disease and other general conditions,SLE-PAH related laboratory examination results,echocardiography,imaging findings and four diagnostic information of traditional Chinese medicine,and through professional data analysis software for analysis,induction,in order to explore the distribution of SLE-PAH syndromes,clinical characteristics,in order to better guide the clinical treatment of traditional Chinese medicine.Results1.General information : This study included 101 patients with SLE-PAH,including 7 males(7.00%)and 94 females(93.00 %).The ratio between men and women is 1 : 13.43.The oldest was 82 and the youngest was 11,with an average age of 40.46 ± 15.10.The longest course is 30 years and the shortest is 2 weeks.Patients with disease duration less than 5 years were the most(54.46 %).2.Distribution of pulmonary hypertension :mild pulmonary hypertension(n = 54,53.47 %),moderate PAH(n = 28,27.72 %),and severe PAH(n= 19,18.81 %).3.Correlation study of SLE-PAH in different degrees :(1)There was no significant difference in age and course of disease among mild,moderate and severe SLE-PAH.(2)Laboratory parameters : WBC,NEU,AST in three groups of SLE-PAH group difference was statistically significant(P<0.05).The WBC level of severe PAH group was higher than that of mild PAH group and moderate PAH pressure group,and the difference was statistically significant(P<0.05).The NUE level of severe PAH group was higher than that of mild PAH group and moderate PAH group,and the difference was statistically significant(P<0.05).Other indicators(age,course of disease,LYM,HGB,PLT,ALT,Crea,Urea,ESR,CRP,autoantibodies,complement)were not statistically different(P>0.05).4.The distribution of TCM syndromes : spleen and kidney yang deficiency syndrome(n = 25,24.75 %),heat toxin and blood stasis(n = 21,20.79 %),wind dampness and heat Bi syndrome(n = 20,19.8 %),qi and blood deficiency(n = 18,17.82 %),liver and kidney yin deficiency(n = 17,16.83 %).5.Correlation study of TCM syndromes :(1)There was no significant difference in age and course of disease among different TCM syndromes(P>0.05).(2)Laboratory indexes : There were statistically significant differences in Crea and Urea levels among the five TCM syndromes(P<0.05).The Crea level of spleen-kidney yang deficiency syndrome was higher than that of liver-kidney yin deficiency syndrome(P<0.05).The level of Urea in spleen and kidney yang deficiency syndrome was higher than that in heat toxin and blood stasis syndrome,liver and kidney yin deficiency syndrome and wind dampness and heat arthralgia syndrome(P<0.05).Other indicators(WBC,NEU,LYM,HGB,PLT,AST,ALT,ESR,CRP,autoantibodies,complement)had no statistical difference(P>0.05).(3)The distribution of TCM syndromes in mild,moderate and severe PAH was different(P<0.05).In patients with mild pulmonary hypertension,the number of patients with rheumatic fever was more than that with spleen-kidney yang deficiency(P<0.05).In patients with severe pulmonary hypertension,the number of patients with spleen-kidney yang deficiency was more than that with liverkidney yin deficiency(P<0.05).Conclusions1.SLE-PAH is a disease that is common in young and middle-aged women.2.In the three groups with different levels of PAH,the levels of WBC,NEU and AST in the severe PAH group were higher than those in the other two groups.3.Among the five TCM syndromes,the spleen-kidney yang deficiency syndrome is the most,and the degree of Crea,Urea and PAH can be used as the reference for clinical TCM syndrome differentiation.