The Experimental Study Of ¹⁸F-FDG PET Radiomics Combined With MTOR/P70S6K Pathway Expression In Predicting Lymphatic Metastasis Of Cervical Squamous Cell Carcinoma

Objective: To explore the performance of 18F-FDG PET radiomics combined with m TOR/P70S6 K pathway expression in predicting lymph node metastasis in patients with SCC and the potential interaction between them.Materials and methods :From 2012 to 2015,100 patients with SCC were retrospectively collected from Shengjing Hospital affiliated to China Medical University with complete clinicopathological data and 18F-FDG PET images.Confirmed by postoperative pathology,there were 40 patients with lymph node metastasis and 60 patients without lymph node metastasis.The radiomic features of 18F-FDG PET imaging were extracted,and the value of SUVmax,radiomic features and the expression level of m TOR and P70S6 K in predicting lymph node metastasis was evaluated by ROC curves,and compared with De Long test.Results :The expression of m TOR,P70S6 K and SUVmax were significantly correlated with lymph node metastasis in SCC.The combination of radiological features and the expression of m TOR/P70S6 K pathway has significant predictive value(AUC=0.940,P < 0.01,95% CI is 0.891-0.988,specificity is 90.007%,sensitivity is 91.67%).In addition,there is a potential correlation between several high-order texture features and the level of m TOR/P70S6 K expression.Conclusion: radiomic features can predict lymph node metastasis in patients with SCC Radiomic features combined with the m TOR/P70S6 K pathway improved the prediction accuracy.In addition,there is a potential correlation between some high-order texture features and the expression of m TOR/P70S6 K pathway.