Clinical Comparative Study Of Trousseau Syndrome And Atrial Fibrillation Associated Cerebral Infarction

Objective: This study was aimed to explore the characteristics and differences of biomarkers,clinical and imaging manifestations among patients with Trousseau syndrome and atrial fibrillation who suffered from acute ischemic stroke,so as to improve clinical understanding of these patients.Methods: This retrospective study consecutivly enrolled 111 patients with acute ischemic stroke who were admitted to our department between January 2019 and January2021.These patients were divided into Trousseau syndrome group(n = 27)and atrial fibrillation group(n = 84).The general clinical features,initial symptoms,average hospitalization days,ICU admission rate,embolism at other sites,platelet count,serum D-dimer and C-reactive protein levels were compared between the two groups.Diffusion weighted imaging(DWI)was used to show the location,quantity and distribution pattern of infarct lesions.Results: Compared with control group,the age(t=0.501,P<0.05)and the history of coronary heart disease(P<0.05)in Troussea syndrome group were lower than those in atrial fibrillation group.There was significant difference in clinical syndrome between the two groups: The proportion of PACS(partial anterior circulation syndrome)(χ~2 =250.60,P<0.01)in Troussea syndrome group was significantly higher than that in atrial fibrillation group,and the proportion of combined syndromes(P<0.05)in TS group was higher than that in atrial fibrillation group.Patients with troussea syndrome had significantly higher serum levels of D-dimer(t—3.709,P<0.01)and CRP(t=2.286,P<0.05)than those in atrial fibrillation group.In terms of the characteristics of DWI lesions,the proportion of Pattern3(multiple punctate disseminated lesions)in the Troussea syndrome group was higher than that in the atrial fibrillation group,and the proportion of anterior and posterior circulation involvement in the affected area in the Troussea syndrome group was higher than that in the atrial fibrillation group.Conclusion: Elevated plasma D-dimer and CRP levels are useful biomarkers for the diagnosis of Trousseau syndrome and differentiate from atrial fibrillation-associated cerebral infarction.Troussea syndrome is easier to form multiple dot-like disseminated lesions than atrial fibrillation,but it is very difficult to distinguish them only by imaging.