| Objective: This study focused on significance of soluble ST2 and Galectin-3 on left ventricular dysfunction diagnosis and assessment of severity in patients with AMI;Secondly,explore the significance of soluble ST2 screening and evaluation of left ventricular dysfunction in patients with NT-pro BNP ≤ their respective age stratification threshold;Finally,explore the evaluation significance of soluble ST2 on the short-term(3-6 months)cardiac function changes in patients with AMI and left ventricular dysfunction.Methods: A total of 101 patients with left ventricular dysfunction during their stay in the hospital were included in this study.These patients were all diagnosed with acute myocardial infarction for the first time.And everyone received emergency coronary intervention.During the treatment in the hospital,the included patients were evaluated by the CS score to evaluate the degree of hyperemia,and divided into 3 groups according to the severity,respectively,group 0(group A,23 cases),group 1-2(group B,59 cases)and group ≥3(group C,19 cases).Basic clinical data of these patients were collected.And carefully record their clinical biochemical indicators within 24 hours after admission and NT-pro BNP within 24 hours after admission and before discharge.Uniform detection of soluble ST2 and Galectin-3 within 24 hours after admission and before discharge.Cardiac ultrasonography was performed within 24 hours after admission,before discharge,and short-term(3-6 months)after discharge,and indicators(LVEF and SV)were collected.Results:1.According to CS score,the difference of basic clinical information between three groups was not statistically significant(p> 0.05).2.The results show that c Tn I(56.40 ± 43.12 in group A;105.76 ± 83.06 in group B;177.47 ± 124.03 in group C)and hs CRP(8.53 ± 12.40 in group A;12.21 ± 27.50 in group B;30.34 ± 31.79 in group C)increased successively(P<0.05);That e GFR(104.05± 15.16 in group A;97.13 ± 22.45 in group B;89.79 ± 25.40 in group C)decreased successively was statistically significant too(P<0.05);However,there was no significant difference in other indicators of patients between the three groups(P>0.05).3.It was statistically significant(P<0.05)that NT-pro BNP(group A 702.11 ± 826.85;group B 1161.11 ± 1438.90;group C 4246.22 ± 8648.02),soluble ST2(group A 34.78 ±9.70;group B 60.47 ± 27.79;group C 205.05 ± 194.35)and Galectin-3(A 3974.98 ±2194.37;group B 4557.90 ± 1663.67;group C 6702.96 ± 2463.21)increased successively;Further row pairwise comparison among the three groups were found between CS score mild and moderate groups,the inter-group difference of soluble ST2 was still statistically significant.4.NT-pro BNP was recorded within 24 hours after admission of the enrolled patients.The above indicators are stratified by age.The patients whose above indicators are less than or equal to their respective age stratification thresholds are screened out.The soluble ST2 of these patients within 24 hours after admission(group A 37.25 ± 9.15;group B 61.95 ± 28.94;group C 240.74 ± 272.35)had differences between the three groups of light,moderate and severe CS scores(p<0.05),but NT-pro BNP within 24 hours after admission did not(p>0.05);Pearson test showed that correlation of soluble ST2 and CS score,admission c Tn I and admission LVEF were positively correlated(r=0.507,p<0.01),positively correlated(r=0.641,p<0.01),and negatively correlated(r=-0.398,p= 0.003).But the correlation between NT-pro BNP and them was not statistically significant(p>0.05).5.The LVEF of re-examination of cardiac ultrasound in the soluble ST2<35ng/ml group before discharge was significantly higher than that of the soluble ST2≥35ng/ml group before discharge(soluble ST2<35ng/ml group 59.04 ± 5.50;soluble ST2≥35ng/ml group 53.46 ± 9.64),and it was statistically significant(p<0.05);The changes of pre-discharge echocardiography LVEF,pre-discharge echocardiography SV and reexamination echocardiography SV were the same,but they were not statistically significant.Further two groups of patients were performed before and after comparison itself,found in patients with soluble ST2<35ng/ml pre-discharge review LVEF increase over the previous cardiac ultrasound,and it was statistically significant(p<0.01);However,there was no statistically significant change in the LVEF of echocardiography in the soluble ST2≥35ng/ml group before discharge(p>0.05).Conclusion:1.In patients with AMI,soluble ST2 and Galectin-3 have certain diagnostic significance for left ventricular dysfunction,as well as evaluation of the severity of left ventricular dysfunction.Which in CS patients with lower scores,soluble ST2 has the greater clinical significance.2.In patients with NT-pro BNP≤ their respective age-stratified community values,soluble ST2 is still available for screening and evaluation of left ventricular dysfunction,at a time when NT-pro BNP lost the screening and evaluation of significance.3.It makes sense that soluble ST2 evaluates the changes of short-term cardiac function in patients with AMI and left ventricular dysfunction. |
PDF Full Text Request