Clinical Features And Related Factors Of Freezing Of Gait In Patients With Parkinson’s Disease

Objective The purpose of this study was to explore the clinical characteristics and related factors of freezing of gait(FOG)in patients with Parkinson’s disease(PD).To provide the basis for clinical recognition,diagnosis and treatment of FOG.Methods The motor and non-motor symptoms of a total number of 77 PD patients were evaluated.Patients with FOG(PD+FOG,n=37 cases)were defined as a score ≥ 1 in the new freezing of gait questionnaire(NFOG-Q).Patients without FOG(PD-FOG,n=37 cases)were defined as a score <1 in the new freezing of gait questionnaire(NFOG-Q).A comparative study between patients with and without FOG was conducted.Results In this investigation,the prevalence of FOG was 48%.The patients with FOG had longer disease duration,higher H-Y stage,higher dose of dopaminergic agents,and higher non-motor and motor symptom scores.A significant positive correlation was found between the NFOG-Q score and the H-Y stage,PIGD subscore,PDQ-39,and the attention/memory in the NMSS subitem(r>0.5,P<0.05).The binary logistic regression analysis showed that the higher H-Y stage,higher rigidity subscore and UPDRS II score,and UPDRS III score were significantly correlated with the occurrence of FOG(P<0.05).Conclusion 1.In this study,we found that the severity of FOG was significantly positively correlated with the H-Y stage,PIGD subscore,PDQ-39 score,and attention/memory score.2.The clinical characteristics of H-Y stage,UPDRS II score,UPDRS III score and rigidity can be used to risk factors for of FOG in PD.