Effects Of Repetitive Transcranial Magnetic Stimulation On Gait And Balance In Parkinson’s Disease Patients

Objective To assess the gait and balance function of Parkinson’s Disease patients,we used The gait balance scale and Walkerview digital treadmill,and conducted the repeated transcranial magnetic stimulation therapy to explore whether the r TMS parameter combination in this study is effective for the gait and balance function of patients with Parkinson’s disease,and to explore a new approach to cure the gait and balance dysfunction of Parkinson’s Disease patients.Methods Parkinson’s Disease patients who were inpatient and met the inclusion criteria from June 2019 to January 2021 were included in our study in Department of Neurorehabilitation,Gan Su Provincial People’s Hospital.The patients are divided into the treatment group and control group,the above two groups of patients finish the conventional gait and balance rehabilitation training,2 times a day,30 minutes each time,6 days per week,2 weeks in total.The treatment group was stimulated with r TMS in addition to gait and balance rehabilitation training.Bilateral cortical motor area(M1 area)was selected,The stimulus frequency was 10 Hz,the intensity was 80%MT,the stimulation time was1.5s,the interval was 10 s,1560 total stimulations and the time of duration was 20 minutes,twice a day,6 times per week,2 weeks in total.The control group was given r TMS pseudo-stimulation treatment on the basis of conventional gait and balance re-habilitation treatment.The parameter setting and treatment time were the same as those in the treatment group,but the coil was placed in reverse and had no stimulation.All of the patients in training before and after 2 weeks should use UPDRS III,Tinetti scale,Berg scale and the evaluation of the digital treadmill to assess gait and balance function,and record the Parkinson’s disease patients gait parameters.Results According to the inclusion criteria,we fit into 42 subjects in total.The object of study were divided into the treatment group(n=21)and the control group(n=21)by table of random numbers,and 42 patients finally completed rehabilitation training without loss.According to the statistics,there was no statistical significance in the clinical baseline level and the results of the initial rehabilitation assessment between the two groups(P>0.05),which indicated that there was comparability between the two groups.Two groups were compared for the first time and after rehabilitation training evaluation data,statistical results show that the two groups of gait(step length and step length coefficient of variation)and balance function,are ascending and statistically significant(P<0.05),while r TMS combined routine rehabilitation group in Parkinson’s disease patients gait and balance function enhance curative effect better than control group(P<0.05).The spatial parameters of gait frequency were lower after training than before training,but there was no statistical significance between and within groups(P>0.05).Conclusion 1.This study shows that r TMS 【 The parameter combination is Bilateral cortical motor area(M1 area)was selected,The stimulus frequency was10 Hz,the intensity was 80%MT,the stimulation time was 1.5s,the interval was10 s and 1560 total stimulations,2 weeks 】 combined with routine rehabilitation training or pseudo-stimulation combined with routine rehabilitation training can improve the gait(step size,coefficient of variation)and balance function in patients with Parkinson’s disease.2.The above r TMS parameters combined with conventional rehabilitation therapy is more superior than r TMS pseudo-stimulation combined with conventional rehabilitation therapy to improve the gait and balance function of patients with Parkinson’s disease.3.The two groups of treatment methods could not improve the pace of Parkinson’s Disease patients.