Clinical Features And Prognostic Factors Of Primary Thyroid Lymphoma

Objective:To investigate the prognostic factors of primary thyroid lymphoma(PTL),and to provide help for clinicians to better diagnose and treat PTL.Methods: The clinical data of 52 patients with primary thyroid lymphoma admitted to the fourth hospital of Hebei Medical University from April 2007 to November 2020 were analyzed retrospectively.In this paper,diffuse large B-cell was analyzed The prognosis factors were analyzed by lymhoma(DLBCL),Kaplan Meier survival curve and log rank test were performed.The results showed that P < 0.05 had significant statistical difference.Because of the small number of mucosa associated lymphama tissue(MALT),descriptive analysis was performed.Results:1.All patients were followed up to February 2021.Of the 52 patients,8died and 44 survived.The 1,3 and 5 year OS was 92%,89.8% and 86.8%respectively,and the 1,3 and 5 year PFS was 85.6%,74% and 71.1%respectively.2.Among the 52 patients,there were 6 cases of dlbcl36(including 1 case of transformation from MALT to DLBCL),6 cases of MALT,4 cases of FL3 a,3 cases of transformation from FL3 a to DLBCL,1 case of marginal zone B-cell lymphoma with plasma cell differentiation,1 case of peripheral T-cell lymphoma and 1 case of Hodgkin’s lymphoma.3.Of the 36 patients with DLBCL,7 died and 29 survived.The 5-year OS and PFS of DLBCL patients were 83.5% and 67.1%,respectively.The5-year OS and PFS were 100%.4.The study on DLBCL patients showed that the OS and PFS of patients with elevatedβ2-microglobulin,IPI score of 2-5,non germinal center type were shorter,with statistical difference.The PFS of patients with age <60 years,Ki67 index≤70%,combined with rituximab treatment was longer,with statistical difference.5.In the study of DLBCL patients,there were no statistical differences in gender,B symptoms,Hashimoto’s thyroiditis,serum LDH level,ECOG score,tumor diameter,clinical stage,treatment method and prognosis(P > 0.05),but there was a tendency to shorten OS and PFS,which may be associated with poor prognosis.Conclusions:1.PTL is a rare disease with good prognosis.The main pathological types are DLBCL and MALT.2.In DLBCL,elevatedβ2-microglobulin,IPI score of 2-5 and non germinal center type were associated with poor prognosis.3.In DLBCL,age <60 years,Ki67 index ≤ 70%,combined with rituximab treatment have a positive impact on the prognosis.4.In DLBCL,gender,B symptoms,Hashimoto’s thyroiditis,serum LDH level,ECOG score,tumor diameter,clinical stage,and treatment methods have a tendency to shorten OS and PFS,which may be associated with poor prognosis.