A Retrospective Observational Study On The Effect And Survival Analysis Of Spinal Cord Astrocytoma

Purpose: Due to their rarity,the treatment standardization and prognostic factors of spinal cord gliomas are still unclear.We aimed to clarify these issues in spinal cord astrocytoma.Methods: Between January 2013 and January 2020,27 patients with spinal cord astrocytoma were enrolled in the study.We retrospectively analyzed preoperative,postoperative,pathological and long-term results of patients with spinal cord astrocytoma through Cox regression analysis and Kaplan‐Meier curves.Results: No statistically significant differences were found among groups regarding age,gender,tumor location,preoperative McCormick score,syringomyelia,radiation and chemotherapy.The mean duration of the symptoms was 3.2 months in the high-grade group and 11.8 months in the low-grade group,the difference was statistically significant(P = 0.005).About 83.3% of the cases had Ki‐67 expression ≥ 5% in the high-grade group,which was higher than 19.0% in the low-grade group,with statistical significance(P =0.008).There was no significant difference in the surgical resection,segment length,operation time,blood loss,postoperative complications and hospital stay(P > 0.05).Age,gender,tumor location,syringomyelia,segment length,radiotherapy and chemotherapy were not risk factors affecting the overall survival rate(P > 0.05).The univariate analysis identified Surgical extent(P = 0.008)and ATRX(0.016)as being significantly associated with OS.Among all patients,WHO grade,postoperative McCormick,Ki‐67 expression and NSE were the independent prognostic factors for survival(P<0.05).Conclusion: We found that the higher WHO grade,higher Ki-67 expression rate,higher NSE expression and the worse the preoperative neurological status,were significantly associated with worse survival of spinal astrocytoma.