Release Of Berberine Hydrochloride And Electrocatalysis Study By Polyaniline-derived Nanomaterials

With the continuous advancement of science and technology,people are gradually innovating the treatment methods of disease,but the use of traditional medicine is still a typical and effective way.However,due to the low solubility of some drugs,their inherent therapeutic efficacy is significantly decreased.It is found that the solubility of drugs can be significantly improved by loading insoluble drugs into mesoporous nanomaterials,because the inherent high specific surface area,rich pore channels and large pore volume of nanomaterials can increase the dispersion of drugs.On the other hand,nanomaterials also play an important role in the confinement effect of drugs,which can effectively improve the solubility of drugs by reducing the crystallinity of drugs.However,the cumbersome preparation process and high cost make the development and application of nanomaterials suffer great obstacles.Therefore,designing a mesoporous nanomaterial that is simple to prepare,low in cost,and can effectively improve the solubility of drugs is a task that researchers still need to challenge.In recent years,nanomaterials with mesopores not only play a key role in the field of medicine,but also attract more and more attention in the field of catalysts.Among many mesoporous nanomaterials,polymer nanocomposites have great potential in drug carrier applications due to their large specific surface area,controllable morphology,and low cost.Here,a simple Fe³⁺assisted aniline polymerization strategy was innovatively proposed to successfully prepare mesoporous polymer nanocomposites and the corresponding derivatives,and the use of the materials as drug carriers and related electrochemical activities were verified and evaluated respectively.The main contents of this research are as follows:1.Using Fe³⁺assisted aniline polymerization strategy,aniline as polymerization monomer,Fe（NO₃）₃·9H₂O as oxidant and inducer,one-pot synthesis of polyaniline-coated cobalt iron oxide compound Co Fe O_x-PANI.The morphological of the material were explored by adjusting the ratio of water and ethanol in the solvent,and the effect of different hydrothermal synthesis temperatures of Co Fe O_x-PANI on the drug-carrying property was also investigated.After that,we conducted relevant drug release experiments on the drug carrier complex under different release media.Data analysis shows that the release rate and degree of release of the drug have been significantly improved.In addition,through a series of stability studies on the drug carrier complex,it is concluded that the drug complex will not be significantly degraded and has good stability.Finally,the biocompatibility of Co Fe O_x-PANI was verified by the cytotoxicity test of the corresponding materials.2.Using Co Fe O_x-PANI as precursor,samples of Co Fe-NC-700,Co Fe-NC-800 and Co Fe-NC-900 were obtained by controlling carbonization temperature at 700,800 and 900℃,respectively.Their morphology and microscopic characteristics were investigated by SEM,EDX,XRD and BTE,and Co Fe-NC-900 was selected as the best drug carrying material.After that,XRD,DSC and FT-IR were used to verify the drug loading.Next,the solubility of the drug carrier complex was evaluated by performing drug dissolution experiments,and it was found that when Co Fe-NC-900 was used as the drug carrier,the dissolution rate and the degree of dissolution of the drug were further improved.We also explored the stability of the drug carrier complex and found that the complex can still maintain good stability under certain conditions of light,temperature and humidity without degradation.In addition,we have conducted magnetic experiments and found that Co Fe-NC has excellent magnetic adsorption properties.Finally,a series of cytotoxicity studies were conducted on drugs,materials and drug material composites to verify the biocompatibility of Co Fe-NC.3.Co Fe-NC gas-solid phosphating treatment to prepare Co Fe P-NC catalyst material.The prepared Co Fe P-NC has excellent electrocatalytic performance,which mainly comes from the synergy between the Co Fe P nanospheres and the carbon skeleton.On the other hand,the PANI-derived carbon network framework avoids agglomeration of Co Fe P nanospheres and enables the active sites in the material to be exposed more effectively.Moreover,the creation of the carbon network framework provides stronger electronic conductivity and structural stability.It can be known from the electrochemical test results that Co Fe P-NC shows extraordinary property whether hydrogen evolution or oxygen evolution.The water decomposition test results have once again verified the excellent electrocatalytic performance of the material,and can maintain excellent stability within 20 hours.