| Background: In recent years,the incidence of diabetes has increased significantly.Diabetes is an independent risk factor for coronary heart disease,and it is an important factor affecting the recovery of cardiac function after coronary artery bypass grafting(CABG).The efficacy and effects of liraglutide in the treatment of diabetes have confirmed that this type of drug can significantly reduce fasting and postprandial blood sugar,and is more in line with physiological characteristics.Liraglutide does not cause severe hypoglycemia,has higher safety,and also has cardiovascular Protection,anti-platelet aggregation and other effects.The purpose of this study was to observe the effect of liraglutide on the perioperative cardiac function of patients with coronary heart disease and type 2 diabetes after coronary artery bypass grafting.Methods: We gave patients who met the inclusion criteria randomized injections of liraglutide(experimental group)or insulin(control group)to control perioperative blood glucose.The primary endpoint of this study was to compare the NT-pro BNP index values of the two groups at 1,3,and 7 days after CABG.The secondary endpoints were: comparison of c Tn I,CK-MB,ALT,CREA,PLT and related coagulation function indexes at 1,3,and 7 days after operation between the two groups;and comparison between the two groups using transthoracic echocardiography at 7 days after operation Measured LVEF,LVEDD and total drainage after surgery.Results: After screening and excluding all the patients,the data of 33 and46 patients in the insulin control group and the liraglutide experimental group were finally analyzed.There was no significant difference in baseline data between the experimental group and the control group before surgery(p>0.05).According to the final statistics,there was no significant difference in blood glucose control indexes between the two groups of patients;the main observation endpoint was that there was no significant statistical difference between NT-pro BNP 1 day after operation(P=0.227,95% confidence interval)and 3 days after operation(P=0.141,95% confidence interval).There was a statistically significant difference between the control group(2790[983,8980]pg/ml)and the experimental group(1650[235,9450] pg/ml)(P=0.000,95%confidence interval)at 7 days after the operation of NT-pro BNP.Secondary endpoints such as CK-MB,c Tn I,ALT,CREA,PLT and coagulation function indexes,as well as LVEF and LVEDD showed no statistically significant differences.The two groups of patients in the experimental group of total drainage(2062[450,3985] ml)and the control group(1410[780,5710]ml)(P=0.034,95% confidence interval)has a significant statistical difference.Conclusion: In patients with type 2 diabetes and coronary heart disease,liraglutide has a certain effect on the improvement of heart function during the perioperative period of simple off-pump coronary artery bypass grafting.Our research results are the same as previous basic research and animal research conclusions,providing clinical evidence.At the same time,it also provides support for the future development of clinical treatment strategies for coronary heart disease complicated with diabetes.Whether liraglutide has a positive effect on the long-term improvement of cardiac function and prevention and treatment of graft restenosis in CABG operation remains to be further observed and studied. |
PDF Full Text Request