A High-resolution MRI Study Of The Correlation Between The Degree Of Atherosclerotic Plaque Enhancement And The Course Of Disease And The Risk Factors Of Intraplaque Bleeding In Patients With Ischemic Stroke

Objective: High resolution magnetic resonance imaging(HR-MRI)was used to investigate the changes in the degree of plaque enhancement that increased intracranial atherosclerotic responsibility over time after an ischemic event and to seek clinical risk factors for intracranial hemorrhage.Methods:1.Patients with intracranial atherosclerotic ischemic stroke who underwent high resolution magnetic resonance examination in the Second Hospital of Hebei Medical University from November 2019 to May 2020 were collected.2.They were divided into acute phase group and non-acute phase group,and the degree of enhancement of responsible plaques in the twogroups was compared.3.The patients were divided into IPH group and NIPH group.The age,gender,hypertension,diabetes,homocysteine,total cholesterol,high-density lipoprotein,low-density lipoprotein,high sensitive C-reactive protein,white blood cell of the two groups were compared.Results: 1.57 patients according to the criteria were collected,including38 males(64.4%)with an average age of(52.3±11.6)years.A total of 158 intracranial atherosclerotic plaques and 57 responsible plaqueswere found.2.In the acute stage group,there were 45 responsible plaques,of which 40 were significantly enhanced,5 were slightly enhanced,and 0 were not enhanced.In the non-acute stage group,there were 12 responsible plaques,7of which were significantly enhanced,3 of whichwere slightly enhanced,and2 of which were not enhanced.The proportion of significantly enhanced plaques in acute stage was higher than that in non-acute stage(P=0.041).There was no difference in the proportionof mild plaque enhancement between the two groups(P>0.05).The proportion of non-enhanced plaques in acute stage was lower than that in non-acute stage(P=0.041).3.The mean age of the IPH group was lowerthan that of the NIPH group(P=0.016),with 7 patients in the IPH group and 50 in the NIPH group.HDL in the IPH group was significantlylower than that in the NIPH group(P=0.002).Conclusions:1.HR-MRI can reflect the stability of plaques through the degree of plaque enhancement and predict the risk of acute ischemic stroke.2.The degree of intracranial plaque enhancement after acute ischemic events will gradually decrease with time.3.Intraplaque hemorrhage may be related to age and HDL cholesterol levels...