| Objective This study collected the medical records of hospitalized patients with atrial fibrillation retrospectively to study the relationship between RDW and atrial fibrillation and to find out whether RDW is a risk factor for atrial fibrillation.Methods The study is a retrospective case-control study.Through strict inclusion and exclusion criteria,70 patients with atrial fibrillation who were hospitalized in the first affiliated Hospital of Inner Mongolia Medical University for the first time from July 2019 to the end of June 2020 were selected as the atrial fibrillation group.Another 70 patients without atrial fibrillation matched with sex,age,smoking history,concomitant disease and medication in the same period were selected as the control group.The clinical data of patients who had been hospitalized in the past were sorted out,and the necessary data were collected,including sex,age,concomitant disease,RDW and other laboratory indexes,echocardiography and so on.The differences of RDW and other indexes between the atrial fibrillation group and the control group were compared,and the relationship between RDW and atrial fibrillation and CHA2DS2-VASc scores was analyzed.According to the onset time of atrial fibrillation,atrial fibrillation is divided into paroxysmal atrial fibrillation and non-paroxysmal atrial fibrillation,including 29 patients with paroxysmal atrial fibrillation and 41 patients with non-paroxysmal atrial fibrillation.The differences of all indexes between paroxysmal atrial fibrillation group and non-paroxysmal atrial fibrillation group were compared in detail,the relationship between RDW,LAD and CHA2DS2-VASc score was analyzed,and the differences of RDW and LAD among different CHA2DS2-VASc score groups(low risk group score: 0,medium risk group score: 1,high risk group score: ≥ 2)were compared.Result 1.There was no significant difference in sex,age,smoking history,concomitant disease and medication between the atrial fibrillation group and the control group(P > 0.05).The RDW of atrial fibrillation group was 13.23% ±1.02%,the RDW of control group was 12.83% ±0.67%;The LAD of atrial fibrillation group was(41.63±7.19)mm,and the LAD of control group was(34.24 ±3.84)mm,there were significant differences between the two indexes in each group(P < 0.01).Multivariate logistic regression analysis showed that: RDW(OR:2.316,95%CI:1.274～4.212,P<0.05)and LAD(OR:1.340,95%CI:1.193～1.206,P < 0.001)were risk factors for atrial fibrillation.The receiver operating characteristic curve showed that the areas under the curve predicted by RDW and LAD were0.625(95%CI:0.532～0.718;P< 0.05)and 0.810(95%CI:0.737～0.883,P < 0.001),respectively.There was no significant correlation between RDW and LAD(r=0.031,P>0.05).The area under the diagnostic curve of combined diagnosis of RDW and LAD was 0.837(95%CI:0.769～0.905;P<0.001).2.There were significant differences in age,platelet,serum creatinine,LAD and RAD between paroxysmal atrial fibrillation group and non-paroxysmal atrial fibrillation group(P<0.05),but there was no significant difference in other indexes between paroxysmal atrial fibrillation group and non-paroxysmal atrial fibrillation group(P >0.05).There was no significant correlation between RDW and CHA2DS2-VASc stroke score(r=0.073 P>0.05).There was no significant difference in RDW and LAD among CHA2DS2-VASc stroke score groups(P > 0.05).Conclusion 1.RDW is closely related to atrial fibrillation,and RDW is an independent risk factor for atrial fibrillation.2.The higher level of RDW is more likely to suffer from atrial fibrillation,and the level of RDW is not related to the type of atrial fibrillation.3.LAD is closely related to atrial fibrillation and is an independent predictor of atrial fibrillation.4.At present,it can not be considered that RDW is related to CHA2DS2-VASc stroke score. |
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