| Objective: To explore the general situation and influencing factors of esophageal cancer patients in western Guangxi region,so as to determine the high-risk groups of esophageal cancer patients and the main risk factors for the occurrence of esophageal cancer,and to provide theoretical basis for comprehensive prevention and treatment of esophageal cancer in western Guangxi region.Methods: Subjects were selected from residents living in western Guangxi for more than15 years.In the case group,patients with esophageal cancer diagnosed by postoperative pathology or endoscopic pathology were selected from the Department of Cardiothoracic and Vascular Surgery,Affiliated Hospital of Youjiang Medical University for Nationalities from January 2017 to December 2020,and 306 patients with relatively complete case data were screened out.n the control group,healthy people who went to the Affiliated Hospital of Youjiang Medical University for Nationalities for physical examination were selected.A 1:1matched case-control study was conducted to select 306 cases who were matched with the case group in terms of gender,age and residence.Most of the subjects could complete the questionnaire by medical history,while some could complete the questionnaire by telephone inquiry.In case group patients age,sex,occupation,histological classification generally descriptive analysis,etc,for possible influence factors related to esophageal cancer in western Guangxi using single factor analysis of single factor Logistic regression analysis,the factors of screening was statistically(P < 0.05),and then to Multinomial Logistic regression analysis,P < 0.05 prompt difference was statistically significant,according to the analysis results and the theoretical basis to determine the west parts of a major risk factor for esophageal cancer.Results:1)Among 306 cases,there were 279 males and 27 females,with a male-to-female sex ratio of 10.3:1;Among them,6 cases(2%)were under 40 years old,51cases(16.7%)were 40-49 years old,93 cases(30.4%)were 50-59 years old,125 cases(40.8%)were 60-69 years old,25 cases(8.2%)were 70-79 years old,and 6 cases(2%)were >80 years old.The mean age of males and females was(57.91±9.259)years and(61.67±11.744)years.2)Among the 306 cases,182 cases(59.8%)had primary school education or below,78cases(25.5%)had junior high school education or technical secondary school education,and45 cases(14.7%)had senior high school education or above.3)Among 306 cases,291 were esophageal squamous cell carcinoma,accounting for95.2%;10 cases of esophageal adenocarcinoma,accounting for 3.3%;5 cases of other rare types,accounting for 1.7%.In pathological tissue differentiation,178 cases were moderately differentiated,accounting for 58.2%;70 cases were highly differentiated(22.9%);There were58 cases with low differentiation or undifferentiation,accounting for 19.0%.Among the tumor lesion sites,165 cases were in the middle esophagus,accounting for 53.9%;103 cases of lower esophagus,accounting for 33.7%;The upper segment of esophagus was 38 cases,accounting for 12.4%.4)The results of single Logistic regression analysis showed that personal history of gastroesophageal cancer,family history of tumor,adverse psychological state,drinking years,dietary rules,eating speed,eating habit of overeating,drinking water sources,eating salted fish and salted products,mildewed food and beans were related to the incidence of esophageal cancer.Multinomial Logistic regression analysis results showed that family history of tumor(P = 0.672 > 0.05),dietary laws(P = 0.272 > 0.05),the source of drinking water(P = 0.103 >0.05),eat salted fish and pickled products(P = 0.966 > 0.05),food mildew(P = 0.086 > 0.05,eat beans(P = 0.211 > 0.05),no statistically significant difference.Drinking alcohol for 10 to20 years(P=0.000,OR=5.031,95%CI: 3.282-10.010),drinking > for 20 years(P=0.001,OR=3.031,95%CI: 1.603-5.730),personal gastroesophageal history(P=0.000,OR=6.359,95%CI: 3.837-10.539),adverse mental state(P=0.000,OR=11.972,95%CI:7.309～19.612),excessive eating speed(P=0.000,OR=3.236,95%CI: 1.794-5.837),excessive eating habit(P=0.000,OR=4.803,95%CI: 2.324～9.927),eating salt fish and bacon(> twice a week)(P=0.041,OR=1.951,95%CI: 1.029～3.699),the above differences were statistically significant,which were risk factors for esophageal cancer in western Guangxi.Conclusion:Esophageal carcinoma patients in the west of Guangxi were mostly in the middle-aged and elderly aged from 50 to 70 years old,with a male to female ratio of 10.3:1.Esophageal squamous cell carcinoma was the main histological type of esophageal cancer patients,accounting for 95.2%.The differentiation degree of esophageal carcinoma was mainly medium differentiation,accounting for 58.2%.The number of years of drinking,personal history of gastroesophageal disease,bad mental state,eating too fast,eating too much,eating salted fish and bacon were positively correlated with the incidence of esophageal cancer in western Guangxi,which were the risk factors related to esophageal cancer in western Guangxi. |
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