| Objective: This research was aimed to explore the correlation between acquired maternal RSV pre-F Ig G or nasopharyngeal mucosal pre-F Ig A antibodies level and clinical severity of RSV infection among the infant younger than 3 months.Methods: A analysis was made on the infants aged less than 3 months old who were admitted to the pulmonary department ward 1 of the Children’s Hospital of Chongqing Medical University from December 2019 to March 2021.According to the detecting results of RSV antigen or RSV nuclear acid,the patients were divided into RSV infected group and RSV non-infected group.The serum pre-F Ig G and nasopharyngeal mucosal pre-F Ig A of the patients were detected by ELISA.The correlation between the antibody levels and the disease severity within the RSV infected patients was analyzed by the software SPSS 26.0.Results: There was no significant difference of serum pre-F Ig G antibody levels between RSV infected and non-infected patients either in the low,medium or high titer groups(P=0.909).There was no significant difference of NPA pre-F Ig A antibody levels between RSV infected and non-infected patients either in the low titer or high titer groups(P=0.666).No significant difference was found between the serum pre-F Ig G antibody levels and different clinical severity groups among the RSV infected infants(P > 0.05).No significant difference was found between the NPA pre-F Ig A antibody levels and different clinical severity groups(P > 0.05).There were significant differences of serum pre-F Ig G levels among RSV infected patients in gestational age,age,(P =0.044,P=0.000 respectively).This suggests that the older the gestational age,the more maternal pre-F Ig G may be obtained,and maternal pre-F Ig G antibodies decreased gradually after birth.Conclusion: The levels of pre-F Ig G antibody in serum and pre-F Ig A antibody in NPA were not related to the clinical severity among RSV infected patients less than 3 months. |
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