| Objective: To systematically evaluate the efficacy of different types of non-invasive brain stimulation,such as low frequency repetitive transcranial magnetic stimulation,high frequency repetitive transcranial magnetic stimulation and transcranial direct current stimulation,on the treatment of aphasia after stroke.Method:Databases of Pub Med,EMbase,Cochrane Library,the Chinese National Knowledge Infrastructure(CNKI),Vip and Wanfang database were searched for randomized controlled trials(RCTs)published before September,2020.Rev Man 5.3、ADDIS 1.16.8 software were used for meta-analysis.Results: A total of 15 studies involving 1058 patients were included,involving 7 types of intervention measures.The results showed that conventional therapy combined with low frequency repetitive transcranial magnetic stimulation or conventional therapy combined with transcranial direct current stimulation was better than conventional therapy.The results of network meta-analysis showed that high frequency r TMS(left)+ conventional treatment,low frequency r TMS+ conventional treatment,bilateral r TMS+ conventional treatment,and t DCS+ conventional treatment were all superior to the conventional treatment group,except for high frequency r TMS(right)+ conventional treatment and sham r TMS stimulation + conventional treatment.The probability distribution showed that high frequency r TMS(left)+ conventional treatment had the highest probability of being the best treatment for aphasia in stroke.Conclusion:Non-invasive brain stimulation can assist the treatment of aphasia after stroke.High frequency repetitive transcranial magnetic stimulation on the left hemisphere combined with conventional therapy has the best efficacy among various non-invasive brain stimulation treatments. |
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