| ObjectiveTo investigate the early clinical effect of neoadjuvant hormonal therapy(NHT)in high-risk prostate cancer patients.MethodsRetrospective analysis 175 prostate cancer patients with high-risk who underwent radical prostatectomy(RP)from January 2017 to January 2020,including 85 patients who take LHRH-A and antiandrogen drug as maximum androgen deprivation method in the NHT group and 90 patients who underwent radical resection of prostate cancer alone in the control group.The changes of prostate volume,PSA and PSA levels after treatment with the positive rate of incisal margin relations were compared in NHT group.Operation time,intraoperative blood loss,hospitalization time,drainage tube indwelling time,positive rate of incisal margin,recovery of urinary function and changes of pathological Gleason scores were compared between the NHT group and the control group.ResultsProstate volume and PSA value of the NHT group were significantly decreased compared with those before treatment,and the decrease degree was related to treatment time,and the difference was statistically significant(P<0.05).The NHT group had shorter operation time,lower positive rate of incisal margin,better recovery of urinary function,and more Gleason scores decline,difference showed statistical significance(P<0.05).There was no significant difference between the two groups in intraoperative blood loss,postoperative hospital stay,and indwelling time of drainage tube(P>0.05).ConclusionNeoadjuvant hormonal therapy can reduce the difficulty of surgery for high-risk prostate cancer,and enable some patients who cannot be resected to obtain the opportunity of radical surgery.At the same time,NHT can reduce the positive rate of incisal margin and shorten the recovery time of postoperative urine control.However it needs to be evaluate on a patient-specific basis.There is no need to wait for PSA to drop to less than0.1ng/ml before surgical treatment. |
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