Analysis Of Serological Characteristics Of Hepatitis E Virus Infection In Chongqing During 2010 To 2019

Objective: To analyze the epidemiologic characteristics of hepatitis E virus(HEV)infection for the people in Chong Qing Municipality during2010 to 2019,and evaluate the significance of hepatitis E virus antibody IgM and IgG for the diagnosis of hepatitis E.method:1.The data and whole clinical medical records of anti-HEV antibodies(IgM and IgG)from The Laboratory Department of the First Affiliated Hospital of Chongqing Medical University between 2010 and2019 are collected.2.The HEV infected trend and distribution about seasons,age and gender for HEV infection are retrospective analyzed.3.The cases what are analyzed for hepatic function index were screened out from the people of HEV infection with whole clinical medical records,and divided into the single anti-HEV IgM positive group,the single anti-HEV IgG positive group,the anti-HEV IgM and IgG double positive group,and the control group.The statistical differences in hepatic function index were analyzed among the four groups by statistical method.4.The history of blood transfusion and the diagnostic case of HE are analyzed in the HEV infected patients with whole medical records,and the coincidence rate between positive anti-HEV antibody and clinical HE diagnosis was determined.Results:1.The total positive rate of anti-HEV antibodies was 8.4%(IgM: 2.4%,IgG: 6.8%)during this period.The HEV infection showed an upward trend,and the positive rate of anti-HEV IgG was mainly cause with the lowest1.7% in 2012 and the highest 12.4% in 2018,but the positive rate of anti-HEV IgM showed no upward trend with the lowest 1.2% in 2016 and the highest 4.2% in 2010.There was no statistical differences between season and genders for HEV infection(P > 0.05).The HEV infection rate of the people under 50 years old was increased with age,and the people more than 50 years old maintained at a high level.2.The hepatic function index of HEV infected patients in different anti-HEV antibodies positive have a difference,and the double positive group is the most serious,and the single anti-HEV IgG positive group have the least damage(P<0.008).3.The diagnostic coincidence rate in the infected patients with different anti-HEV positive antibodies.It was as the highest as 96.3% of the double positive group,and as the lowest as 3.2% in the single anti-HEV IgG positive group(P < 0.017).4.Most people with HEV infection have not received blood transfusion,but the case for 8.5% have received.Conclusion: The cases of HEV infection were increased annually,which mainly came from previous infections.The single anti-HEV IgG positive indicator has limited diagnostic value for hepatitis E.The clinical diagnosis of HE should be based on the combination of liver dysfunction with the anti-HEV double positive or a single anti-HEV IgM positive.Moreover,the detection of HEV RNA and HEV Ag should be considered for the further study of HEV infection.