Altered Brain Structural Topological Properties And Its Correlations With Clinical Characteristics In Episodic Migraine Without Aura

Purpose:To investigate the topological alterations of the whole-brain white-matter structural networks in episodic migraine(EM)without aura.Methods:Forty-five EM patients without aura and 35 age-and sex-matched healthy controls were registered,and underwent diffusion tensor MRI acquisition at interictal.Graph theory-based analyses were then performed for the characterization of brain structural network properties.Pearson correlation analysis was performed on each network metric between the EM patients and healthy controls.Results:The EM patients without aura exhibited abnormal global network properties and local network topology that were characterized by more strongly integrated,more efficient and faster information transferring.These network differences were widely located in occipital,temporal and parietal regions.Additionally,the local efficient of global parameters showed positive correlation with visual analogue scale,and along with disease duration prolonging,the nodal efficiency would be reduced,and the nodal shortest path length would be increased.Headache impact test version 6 score have negative correlation with the nodal shortest path length,and positive correlations with the nodal efficiency.Conclusion:Results indicate that EM patients had aberrant topological structure and make a better understanding of structural connectivity in EM,it may provide imaging evidence for clinical study of migraine pathogenesis.