Evaluation Of Curative Effect Of Acupoint Application In The Treatment Of Allergic Rhinitis And Asthma And The Effect Of Serum IL-33

Objective: To observe the external treatment of traditional Chinese medicine—acupoint application for the treatment of patients with allergic rhinitis and asthma.After treatment,asthma control test form(ACTTM),adult asthma quality of life scale(AQLQ),allergic rhinitis visual analog scale(VAS),Number of acute asthma attacks,number of infections,dose of inhaled corticosteroids,lung function(FEV1,FVC,FEV1-pre,FVC-pre,FEV1/FVC,PEF,FEF25,FEF50,FEF75),interleukin-33(IL-33)and other observational indicators,to evaluate the effect of daily acupoint application on the treatment of allergic rhinitis and asthma,and to add new conventional treatment methods for asthma,allergic rhinitis,and allergic rhinitis-asthma syndrome.Methods: From January 2019 to September 2020,56 patients in the Respiratory Department of the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine who met with asthma and were accompanied by allergic rhinitis were collected and collected from January 2019 to September 2020.They were divided into two groups and randomly assigned..In the acupoint application group,28 cases were treated with traditional Chinese medicine acupoint application combined with basic western medicine treatment(application plan: apply once every seven days from the day of enrollment,and apply traditional Chinese medicine to Tiantu,Fengmen,Dingchuan,Feishu,7 stickers each time,one application for 2-4hours,according to the patient’s skin where the application is applied,the application time can be appropriately reduced to avoid adverse reactions according to the patient’s skin,to avoid adverse reactions);28 cases in the western medicine group were treated with conventional western medicine.Before entering the group and after leaving the group,venous blood(one tube at a time,about 5ml per tube)was drawn from each patient to detect the level of interleukin-33 in the serum.During the observation period,the patients were asked weekly about their condition changes and adverse reactions after obeying,and the patients were followed up every month to test lung function,asthma control scale,adult asthma quality of life score,allergic rhinitis visual analog scale,etc.,treatment period For three months.After statistical analysis of data,the clinical efficacy of "acupoint application" in the treatment of allergic rhinitis-asthma syndrome was explored;further study the correlation between acupoint application and serum cytokine IL-33 content.Result:1.Gender,age,BMI(weight/height 2)and other basic information of the acupoint application group and western medicine group,and the observation indicators of lung function,ACTTM,AQLQ,VAS,IL-33,etc.before joining the group,there was no statistical difference(P >0.05),comparable.2.IL-33: After comparing with before treatment,there was no statistical difference in the serum IL-33 content between the two groups of patients(P=0.291>0.05);after treatment,the serum IL-33 content in the two groups was compared,no statistics The difference between the two groups was statistically significant(P=0.490>0.05);the improvement of serum IL-33 before and after treatment was compared between the two groups,and the difference in the amount of improvement was statistically significant(P=0.000<0.05).3.After treatment of the two groups of patients,compared with the same period last year in March,the total number of acute attacks and the total number of infections were significantly lower than that of last year;after treatment,the patients’ basic western medicines did not change significantly(P>0.05).4.ACTTM: The scale was tested before enrollment,4 weeks,8 weeks,and 12 weeks.Analysis: Before treatment,the acupoint application group and the western medicine group were well controlled,poorly controlled,and poorly controlled.P The value was0.851>0.05,and the difference was not statistically significant.Before and after treatment,the three-level analysis of the acupoint application group obtained: P was0.032<0.05;after treatment,the P value of the two groups was 0.017<0.05,which was statistically significant.5.AQLQ: After treatment,there was no statistical significance in AQLQ activity,symptoms,psychology,stimulus,self-care,and total scores of patients in the Western medicine group alone after treatment(P>0.05);comparisons within the acupoint application group except AQLQ-Psychology(P=0.126>0.05),AQLQ-stimulus(P=0.169>0.05),AQLQ-self-care(P=0.130>0.05),the other differences were statistically significant(P<0.05);two groups of patients There was no statistically significant difference between the groups(P>0.05).6.VAS: After treatment,in addition to the symptoms of runny nose and nasal itching,sneezing and nasal congestion in the acupoint application group were all improved,and compared with the western medicine group alone,the difference was statistically significant;the comparison between the two groups of patients,the western medicine group alone did not There was a statistical difference(P>0.05),and there were statistical differences in the application group except for nasal congestion(P<0.05).7.Pulmonary function: After treatment,the pulmonary function test values of the two groups of patients were compared between the groups P>0.05;after three months of treatment,the pulmonary function of the acupoint application group patients at the12 th week improved compared to the time when the group was enrolled,and the P value of FEV1 The P value of FVC-pre is 0.040,the P value of FVC-pre is 0.010,the P value of FVC is 0.047,and the P value of PEF is 0.032<0.05,which are statistically different.Conclusion:1.This study found that during the three-month clinical trial,acupoint application combined with conventional Western medicine treatment can significantly reduce the number of acute attacks in patients,improve asthma control,symptoms of allergic rhinitis,and improve lung function and life of patients The quality and curative effect are better than pure western medicine treatment.2.Acupoint application is a safe and effective traditional Chinese medicine treatment method,which reduces the serum cytokine IL-33 content,which can effectively control the condition of allergic rhinitis-asthma syndrome.No adverse reactions have been seen.It has certain clinical reference value..