| PurposeBy collecting the information of four diagnoses,general data,anxiety grade and clinical objectification indicators of patients with CHD complicated with GAD,to explore the characteristics of the distribution of TCM syndromes of CHD complicated with GAD and its correlation with each indicator,so as to provide more reference for TCM syndrome differentiation treatment of CHD complicated with GAD.MethodsA total of 226 patients who were diagnosed with CHD in the Department of Cardiovascular Diseases of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from June 2020 to January 2021 were selected as the survey subjects,and filled in for evaluation The Generalized Anxiety Disorder Scale(GAD-7).The scale of generalized anxiety disorder(GAD-7)was completed to evaluate anxiety state.All the cases can be divided into two groups by the results:the group with GAD and the group which didn’t complicated with GAD.Collect the patient’s four-diagnosis information of traditional Chinese medicine.According to the survey results,two doctors with senior professional titles in the Department of Cardiology will classify the patients dialectically according to the"Guidelines for the Diagnosis and Treatment of Common Diseases in Traditional Chinese Medicine"and"Chinese Medicine Internal Medicine".And collect the patient’s gender,age,smoking history,drinking history,comorbid diseases and other general data,as well as objective indicators such as blood lipid level,blood coagulation function,and carotid ultrasound.Establish an Excel database,use SPSS26.0 statistical software to perform statistical analysis on the collected data,and summarize the statistical analysis results to draw the final conclusion.Results1.There were 100 females and 51 males in patients with CHD complicated with GAD,and 25 females and 20 males in patients with CHD without GAD.The proportion of women with generalized anxiety disorder was higher,and the difference was statistically significant(P<0.05).2.There were 110 patients with no smoking history and 41 patients with smoking history in patients with CHD complicated with GAD group;there were 36 patients without smoking history and 39 patients with smoking history in patients with CHD without GAD group.There was significant difference in smoking history between patients with CHD complicated with GAD and those without GAD(P<0.05).3.There were 137 patients without drinking history and 14 patients with drinking history in patients with CHD complicated with GAD group;there were 49 patients without drinking history and 26 patients with drinking history in patients with CHD without GAD group.There was significant difference in drinking history between patients with CHD complicated with GAD and those without GAD(P<0.05).4.There were 113 cases without heart failure history and 18 cases with heart failure history in patients with CHD complicated with GAD group.There were 57 cases without heart failure history and 18 cases with heart failure history in patients with CHD without GAD group.There was significant difference in the history of heart failure between patients with CHD complicated with GAD and those without GAD(P<0.05).5.There were significant differences in gender,smoking history and drinking history between different anxiety degree of CHD complicated with GAD(P<0.05).6.There was a statistically significant difference in anxiety levels between Qi stagnation cardiothoracic syndrome and other syndromes coronary in patients with CHD complicated with GAD(P<0.05).7.The risk of syndrome differentiation of patients with drinking history was 7.257times that of patients without drinking history(OR=7.257,95%CI 1.736-30.342);each increase in N by 1×10~9/L,the risk of syndrome differentiation as syndrome of qi stagnation increased 0.709 times(OR=1.709,95%CI 1.141～2.559);the risk of syndrome differentiation for patients with moderate anxiety is 13.608 times that of patients with mild anxiety(OR=13.608,95%CI 4.692～39.472),and patients with severe anxiety are at risk of syndrome differentiation.The risk of Qi stagnation cardiothoracic syndrome is 33.549 times that of patients with mild anxiety(OR=33.549,95%CI 4.243～265.288).The risk of syndrome differentiation of Qi-stagnation cardio-thoracic syndrome in patients with a history of diabetes is 29.4%of patients without a history of diabetes(OR=0.294,95%CI 0.098～0.882).8.The risk of blood stasis syndrome with arrhythmia history was 3.933 times that of patients without arrhythmia history(OR=3.933,95%CI 1.415-10.928).9.The risk of cold congealing heart pulse syndrome in patients with arrhythmia history was 4.107 times that of patients without arrhythmia history(OR=4.107,95%CI 1.481-11.392).Conclusion1.Compared with patients without generalized anxiety disorder,the proportion of women in patients with CHD complicated with GAD was higher,and the proportion of smoking and drinking history was lower.2.In patients with CHD complicated with GAD,the degree of anxiety of women was more serious than that of men,the degree of anxiety of patients without smoking history was more serious than that of patients with smoking history,and the degree of anxiety of patients without drinking history was more serious than that of patients with drinking history.3.The anxiety degree of CHD complicated with GAD with qi stagnation cardiothoracic syndrome was significantly higher than that of other syndrome types.4.Drinking history,neutrophil count and degree of anxiety were independent risk factors of qi stagnation cardiothoracic syndrome.5.The history of arrhythmia is an independent risk factor for CHD with GAD syndrome differentiation as heart blood stasis syndrome and cold coagulation heart pulse syndrome. |
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