Clinical Observation Of Fatty Liver Prescription In The Treatment Of Non-alcoholic Steatohepatitis

Objective:Based on the guidance of the supervisor and previous studies,this study observed the clinical efficacy of fatty liver prescription in the treatment of Nonalcoholic steatohepatitis(NASH)by comparing the relevant experimental indexes before and after treatment.It is expected to provide a safe and effective clinical experience for the treatment of NASH,which is of great value for the exploration of new treatments for NASH.Method:Patients with nonalcoholic steatohepatitis were collected from the inpatient department and outpatient department of hepatobiliary disease department of Jiangxi Hospital of Traditional Chinese Medicine,and 60 cases of NASH patients meeting the diagnostic criteria,inclusion criteria and exclusion criteria of this study were selected.They were randomly assigned to the control group and the treatment group,with 30 cases in each group.There was no significant difference in age,gender,body mass index(BMI)and disease duration between the two groups(P> 0.05),indicating comparability.Two groups are guided by the clinician to diet control,exercise therapy,and ammonium glycyrrhetate capsule treatment,the treatment group to add with the Chinese traditional medicine prescription,fatty liver,two groups of treatment for 12 weeks,Observe the changes of body mass index(BIM),liver function,blood lipid,liver color ultrasound and other indexes of the two groups before and after treatment,and conduct statistics on the collected data to analyze and compare the treatment efficacy of the two groups Results(1)Comparison of changes in body mass index(BMI)showed that after treatment,the body mass index of 2 groups was lower than that before treatment,with statistical significance(P < 0.05).After treatment,the body mass index of patients in the treatment group decreased more obviously than that in the control group,with statistical significance(P < 0.05).(2)Comparison of changes in liver function: After treatment,ALT,AST and GGT in serum of 2 groups were decreased compared with before treatment,with statistical significance(P < 0.05).After treatment,ALT,AST and GGT in the treatment group decreased more obviously than those in the control group,the difference was statistically significant(P < 0.05).(3)Comparison of changes in blood lipid: After treatment,serum TC and TG of 2 groups decreased compared with before treatment,the difference was statistically significant(P < 0.05).After treatment,the serum TC and TG in the treatment group decreased more obviously than that in the control group,with statistical significance(P < 0.05).(4)Comparison of curative effect of liver color ultrasound: The total effective rate of the treatment group was 86.67%,and the total effective rate of the control group was 63.33%,the difference was statistically significant(P< 0.05).(5)In terms of safety,both groups of patients showed normal safety tests during the study period,without any discomfort symptoms such as allergy,nausea,vomiting,palpitation,etc.It indicated that the treatment plan of the treatment group and the control group was safe and reliable.Conclusion:Based on diet management combined with regular exercise,fatty liver formula has a definite effect on NASH treatment.Compared with only using diammonium glycyrrhizinate capsule to treat this disease,fatty liver formula combined with diammonium glycyrrhizinate has a better effect in improving patients’ liver function,blood lipid,body mass index and color ultrasound results.The safety evaluation during the treatment was good,and no adverse events occurred in both groups.This indicates that fatty liver prescription is safe and effective,and can be further applied in clinical practice.