Clinical Research Of 3D Printing Template-assisted ¹²⁵I Particle Implantation On Hepatic Malignant Tumor

Objective:To analyze the feasibility and safety of 3D printing template-assisted125I particle implantation in malignant liver tumors and provide more evidence for the future application and promotion of this technology.Methods:To retrospectively analyze the clinical data of patients with malignant tumors who underwent ¹²⁵I seed implantation in our hospital rom May 2018to May 2020,and set the 3D printing template assisted seed implantation as the experimental group.Simple CT guided seed implantation was set as the control group.We need to transmit the enhanced CT images to the TPS system within 1 week before the seed implantation operation and complete the preoperative plan for seed implantation.The experimental group needs to print out the 3D template according to the preoperative plan,and perform seed implantation under the 3D template.the control group performed seed implantation with hand under CT guidance according to the preoperative plan.The operation time,the number of CT scans,the number of implanted needles,the number of particles,the activity of the particles and the prescribed dose were compared between the two groups of patients,and the postoperative dose parameters such as D90,D100,V100,and V150 were compared between the two groups.The two groups were compared for complications such as bleeding,pain at the puncture site,postoperative fever,pneumothorax,and particle displacement during the operation and within 24hours after the operation.To compare the effective rate of patients 3 months after operation.Results:According to the inclusion and exclusion criteria,a total of 45 patients were included,including 20 in the experimental group and 25 in the control group.Both groups successfully completed 125I radioactive particle implantation,and there was no statistically significant difference in basic data between the two groups.There was no statistical difference between the two groups of patients in the number of implanted needles,the number of particles,the activity of the particles and the prescribed dose.Compared with the control group,the operation time of the experimental group was shorter.There are fewer times of scanning,and the difference is statistically significant.The D90 and D100 of the experimental group were closer to the prescribed dose,V100 was closer to 100%,and V150 was smaller than that of the control group.The dose distribution was more accurate,and the difference was statistically significant.There was no statistically significant comparison between the two groups of patients in the 3-month treatment effective rate.No serious complications occurred in the two groups.The incidence of complications in the control group was higher than that in the experimental group,but it was not statistically significant.Conclusion:The application of 3D printing template-assisted radioactive seed implantation in the treatment of malignant liver tumors can shorten the operation time,optimize radiation dose,improve the operation safety,reduce the times of scanning and the incidence of complications,which has clinical significance.