| Objective:To observe the clinical efficacy of Shenlingbaizhu powder combined with traditional Chinese medicine washing and golden ointment in the treatment of psoriasis vulgaris in children with spleen deficiency and blood-heat syndrome,and the changes in the levels of peripheral blood T lymphocyte subsets of patients before and after treatment.Preliminarily explore the mechanism of action of Shenlingbaizhusan plus or minus combined with traditional Chinese medicine washing and golden ointment for psoriasis in children.Methods:According to the diagnostic criteria of traditional Chinese and Western medicine developed in this subject,60 children with psoriasis vulgaris with spleen deficiency and blood-heat syndrome were selected and randomly divided into two groups.The observation group was treated with Shenlingbaizhu San plus flavor combined Chinese medicine external washing and golden ointment sealing treatment;the control group was treated with compound glycyrrhizin tablets combined with traditional Chinese medicine external washing and golden golden ointment sealing treatment.Both groups of patients were treated with this experimental method for 3 months.Observe and record the treatment and treatment of each child At the 8th week,the skin lesion area,skin lesion color and other symptoms and signs,as well as changes in the level of peripheral blood T lymphocyte subsets;at the same time,record the type of adverse reactions that occurred during the experiment,the time of appearance and disappearance;at the end of the experiment A return visit will be made within the next 8 weeks to understand the recurrence of all children.Results:1.Before the experiment,the gender,age,course of disease,and skin lesion morphology of the two groups of children were collected,and the values of peripheral blood T lymphocyte subsets were tested.At the same time,the PASI score was performed for the symptoms of the patients’skin lesions;The gender,age,skin lesion morphology,PASI score,peripheral blood T lymphocyte subsets(CD4~+T cells,CD8~+T cells and CD4~+/CD8~+values)of the two groups of children were found to be no significant difference(P>0.05);Before the experiment,the two groups of peripheral blood T lymphocyte subpopulation values were also compared with the peripheral blood T lymphocyte subpopulation values of the healthy group,and it was found that the two groups were significantly different from the healthy group(P<0.05).The results show that this experiment can determine the degree of treatment of the disease by the two groups of drugs based on the changes in the value of T lymphocyte subsets.2.After the end of the experimental period,the two groups of experiments were compared in terms of clinical efficacy,PASI scores,laboratory indicators(peripheral blood T lymphocyte subsets),adverse reactions,and recurrence rates within 3 months.The results showed that:relative to the control As far as the group is concerned,the total effective rate and recovery rate of the observation group are higher;the PASI scores of the two groups after the end of the experiment period are lower than before the experiment,but the observation group decreases more significantly;among the laboratory indicators,the treatment cycle After the end,the CD4~+(%)and CD4~+/CD8~+values of the two groups increased,and the CD8~+(%)decreased compared to before the experiment,but the changes in the laboratory indicators of the control group were smaller than those of the observation group;during the experiment,Compared with the control group,the adverse reactions of the observation group were significantly lower;after the treatment period,the recurrence rates of the two groups were compared.The result:compared with the control group,the observation group had an obvious recurrence rate within 3 months after the experiment ended.Lower;and all the above comparisons are statistically significant.in conclusion:1.Oral Shenlingbaizhu powder combined with traditional Chinese medicine washing and golden ointment pack and oral compound glycyrrhizin tablets combined with Chinese medicine external washing and golden ointment pack two treatment options are effective in the treatment of psoriasis in children;and Shenling Compared with the treatment plan of the compound glycyrrhizin group,the treatment plan of the Baizhusan modified group not only has a better therapeutic effect,but also has fewer adverse reactions and a lower recurrence rate.2.The mechanism of oral administration of Shenlingbaizhu powder combined with external washing of Chinese medicine and golden ointment packaging may be related to improving the level of T lymphocyte subsets(CD4~+,CD8~+,CD4~+/CD8~+)in the peripheral blood of patients to achieve the treatment of diseases. |
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