Single Cell Transcriptome Sequencing Mapping Of Organ Development After Implantation Of Cynomolgus Macaca Embryos

The early embryonic development of mammals is determined by the fate of cells at multiple levels and forms the whole developmental blueprint of organogenesis and morphogenesis,which is one of the most important molecular events of life.Early embryonic development is accompanied by the maintenance and differentiation of totipotency and the sequence determination of various pluripotent stem cells.The regulation of this process has a profound effect on the development of the whole embryo.Embryonic development in primates after implantation is an important fundamental biological problem and has important theoretical significance for medical translational applications.Since human materials are difficult to obtain,systematic single-cell transcriptome studies on post-implantation embryos of non-human primates can provide valuable information.30 days based on cynomolgus monkey 46 days and 70 days,40 days,several key points for single-cell transcriptome sequencing,embryonic development preliminary found all vital organs development of cell types,and marker genes,added to the primate cells on the map,embryonic development in understanding of primates that includes people,after implantation embryo development have very important meaning.